Proximal gastric vagotomy with carbon dioxide laser: Experimental studies in animals

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Surgery; (USA)

OSTI ID:6713840

Kadota, T; Mimura, K; Kanabe, S; Ohsaki, Y; Tamakuma, S ^[1]

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1. National Defense Medical College, Saitama (Japan)

Proximal gastric vagotomy has been widely used as a surgical treatment for peptic ulcer disease. However, it is technically complex and time-consuming. Moreover, it may cause circulatory problems in the gastric mucosa. We have reported a new method of blood flow-preserving vagotomy with a carbon dioxide laser (CO2 laser vagotomy) developed in our laboratory. To assess its efficacy, we used cysteamine-induced ulcer and measured gastric mucosal blood flow in rats. The incidence of cysteamine-induced ulcer formation was reduced significantly in the group that underwent CO{sub 2} laser vagotomy compared with a group treated with proximal gastric vagotomy. Gastric mucosal blood flow was significantly better in the CO{sub 2} laser vagotomy group. Long-term follow-up of acid reduction was evaluated in dogs by the pentagastrin-stimulation test. Acid reduction in dogs was satisfactory during the 12 months of this study. CO{sub 2} laser vagotomy is a new, easy, time-saving, and circulatory-preserving technique for peptic ulcer disease.

• OSTI ID: 6713840
• Journal Information: Surgery; (USA), Vol. 107:6; ISSN 0039-6060
• Country of Publication: United States
• Language: English

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DIGESTIVE SYSTEM DISEASES
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NATIONAL ORGANIZATIONS
ORGANIC COMPOUNDS
ORGANS
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POLYPEPTIDES
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560400* - Other Environmental Pollutant Effects