Protection against cis-dichlorodiammine Pt (II) cytotoxicity in vitro by cysteamine

Journal Article · Mon Mar 01 00:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90689-7· OSTI ID:6712648

Shrieve, D C; Harris, J W

EMT6/SF cells exposed to cis-dichlorodiammine Pt (II) (DDP) for 1 hr in the presence of 10 mM cysteamime (MEA) survived better than cells treated with DDP alone (DMF-3.1). MEA added to cultures after removal of DDP also protected, even when the two exposures were separated by as long as 4 hr. Protection by MEA was concentration dependent: no significant protection was observed below 1 mM and maximum protection required 5 mM. When cells were incubated with 10 mM MEA immediately after removal of DDP, survival increased as a function of the length of exposure to MEA, reaching a maximum at 2 hr.

• OSTI ID: 6712648
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:3/4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MEA
BIOLOGICAL EFFECTS
PLATINUM
TOXICITY
CELL CULTURES
IN VITRO
RADIOPROTECTIVE SUBSTANCES
TUMOR CELLS
AMINES
ANIMAL CELLS
DRUGS
ELEMENTS
METALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PLATINUM METALS
THIOLS
TRANSITION ELEMENTS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)