The distribution of copper in neonatal mottled mutant mice after exposure to copper and penicillamine

Journal Article · Sun Aug 01 00:00:00 EDT 1982 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(82)90326-5· OSTI ID:6710416

Hunt, D M; Port, A E

Tissue copper levels of brindled (Mo/sup br/) mice and normal littermates after single and repeated dosing with CuCl/sub 2/ and/or D-penicillamine are examined, together with a study of the cytosol distribution of copper after CuCl/sub 2/ treatment. The results confirm that the mutant mouse kidney is capable of extensive copper accumulation in association with the low MW copper-binding protein. Deficient tissues such as brain, heart and spleen are able to sequester sufficient of the exogenous copper to raise their levels to the normal control level, whereas mutant liver levels, even after copper treatment, remain below normal, indicating that the Mo gene affects the ability of the liver to retain copper.

• Research Organization: Univ. of London, United Kingdom
• OSTI ID: 6710416
• Journal Information: Life Sci.; (United States), Vol. 31:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
COPPER
BIOLOGICAL ACCUMULATION
TISSUE DISTRIBUTION
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MODELS
GENETIC CONTROL
KIDNEYS
MICE
MUTANTS
NEONATES
RETENTION
ANIMALS
BODY
CONTROL
DISTRIBUTION
ELEMENTS
KINETICS
MAMMALS
METALS
ORGANS
PEST CONTROL
REACTION KINETICS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
550500* - Metabolism