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Title: Schistosoma japonicum: An ultraviolet-attenuated cercarial vaccine applicable in the field for water buffaloes

Water buffaloes were vaccinated three times with 10,000 Schistosoma japonicum cercariae irradiated with ultraviolet (uv) light at a dose of 400 microW x min/cm2. The irradiation was performed with cheap, simple, and portable equipment in a rural area of Hubei Province (People's Republic of China). A challenge infection of 1000 untreated cercariae was given to six vaccinated and six naive control buffaloes, while two vaccinated animals were not challenged. The experiment was terminated 6 weeks after the challenge. Control animals had lost body weight and harbored a mean of 110 worms and 37 eggs per gram of liver. The vaccinated animals gained weight after the challenge and developed 89% resistance to infection with S. japonicum. Since schistosomiasis japonica is nowadays transmitted in China predominantly by domestic livestock, a uv-attenuated cercarial vaccine for bovines may contribute to the control of this disease.
Authors:
; ; ; ;  [1]
  1. (Tongii Medical Univ., Wuhan, Hubei Province (China))
Publication Date:
OSTI Identifier:
6705117
Resource Type:
Journal Article
Resource Relation:
Journal Name: Experimental Parasitology; (USA); Journal Volume: 71:1
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BUFFALO; SCHISTOSOMIASIS; SCHISTOSOMA; INFECTIVITY; CHINA; ULTRAVIOLET RADIATION; VACCINES; WEIGHT; ANIMALS; ASIA; DISEASES; ELECTROMAGNETIC RADIATION; HELMINTHS; INFECTIOUS DISEASES; MAMMALS; PARASITIC DISEASES; PLATYHELMINTHS; RADIATIONS; RUMINANTS; TREMATODES; VERTEBRATES 553003* -- Agriculture & Food Technology-- Pest & Disease Control-- (1987-)