The central nervous system effects of carbon disulfide in male albino rats utilizing the tritiated 2-deoxyglucose method

Miscellaneous · Sun Jan 01 00:00:00 EST 1989

OSTI ID:6703022

Wells, III, W E

The methodology employed was the autoradiographic 2-deoxyglucose method. Due to the coupling between functional activity and energy metabolism, these autoradiographs can be likened to a stain for functional activity under varying physiological and pathological states. Exposure regimes consisted of intraperitoneal injections of: (1) 400 milligrams of carbon disulfide per kilogram body weight five days per week for eight weeks; (2) 600 milligrams of carbon disulfide per kilogram body weight for five consecutive days; (3) 800 milligrams of carbon disulfide per kilogram body weight for only a single injection. Qualitative and quantitative analyses of the autoradiograms were employed. Appropriate statistical techniques were then be used to test for significant differences in the optical densities of structures between experimental and control radiographs. The results indicate a significant effect across all levels of analyses for the eight week group and the five day group for the auditory and olfactory central pathways.

• Research Organization: South Carolina Univ., Columbia, SC (USA)
• OSTI ID: 6703022
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARBON SULFIDES
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM
SENSITIVITY
AUTORADIOGRAPHY
BIOLOGICAL PATHWAYS
DISULFIDES
INTRAPERITONEAL INJECTION
RATS
TRITIUM COMPOUNDS
ANIMALS
CARBON COMPOUNDS
CHALCOGENIDES
HYDROGEN COMPOUNDS
INJECTION
INTAKE
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
SULFIDES
SULFUR COMPOUNDS
VERTEBRATES
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