Interaction of irradiation and microwave-induced hyperthermia in the Dunning R3327G prostatic adenocarcinoma model
The interaction of radiation and hyperthermia was systematically studied in the Dunning R3327G prostatic adenocarcinoma, the preeminent animal model for human prostatic cancer. Subcutaneous tumors (produced by injection of 10(7) cells) were treated when they had reached a volume of about 1 cm3, which occurred about 3 weeks after implantation. With the use of a randomized complete factorial design, four factors were examined. Each agent was used at one of three dose levels. For radiation, these were 5, 15, and 25 Gy; for hyperthermia, 42 degrees C for 15 minutes, 43 degrees C for 30 minutes, and 44 degrees C for 60 minutes. Two sequences (hyperthermia plus irradiation and irradiation plus hyperthermia) and five time delays between agents (0, 12, 24, 48, and 120 hours) were used. The growth delay (the time it took for the initial tumor volume to double) of subcutaneously implanted tumor served to quantitate treatment effect. Significant (P less than .05) statistical interactions were observed for several combinations of factors and individual factors. Hyperthermia plus irradiation was more effective than irradiation plus hyperthermia except at the delay time between treatments of 0 hours. Peak growth delay occurred when the time between treatments was 0-24 hours and depended on agent doses. Many combinations produced therapeutic synergy.
- Research Organization:
- Univ. of Miami School of Medicine, FL (USA)
- OSTI ID:
- 6698087
- Journal Information:
- Radiology; (United States), Vol. 169:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
HYPERTHERMIA
BIOLOGICAL EFFECTS
MICROWAVE RADIATION
PROSTATE
CARCINOMAS
TUMOR CELLS
GROWTH
BIOLOGICAL MODELS
EXPERIMENTAL NEOPLASMS
RATS
ANIMAL CELLS
ANIMALS
BODY
BODY TEMPERATURE
DISEASES
ELECTROMAGNETIC RADIATION
GLANDS
MALE GENITALS
MAMMALS
NEOPLASMS
ORGANS
RADIATIONS
RODENTS
VERTEBRATES
560400* - Other Environmental Pollutant Effects
550900 - Pathology