Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse

Journal Article · Fri Jan 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1002· OSTI ID:6697571

Luongo, C; Gould, K A; Moser, A R ^[1]; Su, Likuo; Kinzler, K W; Vogelstein, B ^[2]; Dietrich, W; Lander, E S ^[3]

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1. Univ. of Wisconsin, Madison (United States)
2. Johns Hopkins Oncology Center, Baltimore, MD (United States)
3. MIT, Cambridge (United States)

The Min (multiple intestinal neoplasia) mutation of the mouse has been mapped by analyzing the inheritance of restriction fragment length polymorphisms and simple sequence length polymorphisms in progeny from two intraspecific crosses segregating for the Min mutation. Min, a mutant allele of Apc, the mouse homo- log of the human APC (adenomatous polyposis coli) gene, maps to proximal chromosome 18. The synteny between Apc and Mcc, the mouse homolog of the human MCC (mutated in colorectal cancer) gene, is conserved between mouse and human, although the gene order in the Apc to Mcc interval is different from that in the APC to MCC interval. 29 refs., 3 figs.

• OSTI ID: 6697571
• Journal Information: Genomics; (United States), Vol. 15:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
NEOPLASMS
GENETIC MAPPING
CHROMOSOMES
GENE MUTATIONS
LARGE INTESTINE
LENGTH
MAPS
PROGENY
BODY
DIGESTIVE SYSTEM
DIMENSIONS
DISEASES
GASTROINTESTINAL TRACT
INTESTINES
MAPPING
MUTATIONS
ORGANS
550400* - Genetics