Randomized study of whole-abdomen irradiation versus pelvic irradiation plus cyclophosphamide in treatment of early ovarian cancer

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(90)90369-V· OSTI ID:6695663

Sell, A; Bertelsen, K; Andersen, J E; Stroyer, I ^[1]

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1. Arhus Univ. Hospital (Denmark)

From 1 September 1981 to 1 January 1987, 118 patients with FIGO Stage IB, IC, IIA, IIB, and IIC epithelial ovarian cancer were randomized to abdominal irradiation or pelvic irradiation + cyclophosphamide. There was no difference between the regimens with respect to recurrence-free survival (55%) and 4-year overall survival (63%). At routine second-look laparotomy, 16% of patients without clinical detectable tumor showed recurrence. Twenty-five percent of the patients treated with pelvic irradiation + cyclophosphamide had hemorrhagic cystitis, probably caused by radiation damage and cyclophosphamide cystitis. Eight percent had late gastrointestinal symptoms requiring surgery.

• OSTI ID: 6695663
• Journal Information: Gynecologic Oncology; (USA), Vol. 37:3; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
COMBINED THERAPY
OVARIES
ABDOMEN
ANTINEOPLASTIC DRUGS
INTESTINES
MAN
PATIENTS
PELVIS
SURVIVAL CURVES
ANIMALS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DISEASES
DRUGS
FEMALE GENITALS
GASTROINTESTINAL TRACT
GONADS
MAMMALS
ORGANS
PRIMATES
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine