Failure of low doses of /sup 131/I to ablate residual thyroid tissue following surgery for thyroid cancer
Thirteen patients received an initial dose of 25-29.9 mCi (925-1106 MBq) of /sup 131/I following partial thyroidectomy for papillary, follicular, or mixed carcinoma. Administration of thyroxine (T/sub 4/) or triiodothyronine (T/sub 3/) was stopped 3-12 weeks and 1-6 weeks, respectively, before therapy or imaging. Patients remained on normal diets and did not receive thyroid stimulating hormone (TSH) or diuretics. Follow-up 3 months to 2 years after therapy demonstrated that ablation of thyroid bed activity was successful in only one patient, who still had metastases. This suggests that administration of 25-29.9 mCi of /sup 131/I following surgery is unreliable for ablation of residual thyroid bed activity.
- Research Organization:
- Veterans Administration Medical Center, Denver, CO
- OSTI ID:
- 6687669
- Journal Information:
- Radiology; (United States), Vol. 137:3; Conference: 65. scientific assembly and annual meeting of the Radiological Society of North America, Atlanta, GA, USA, 25 Nov 1979
- Country of Publication:
- United States
- Language:
- English
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Feasibility of low doses of I-131 for thyroid ablation in postsurgical patients with thyroid carcinoma
Feasibility of low doses of I-131 for thyroid ablation in postsurgical patients with thyroid carcinoma
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CARCINOMAS
BIOLOGICAL RADIATION EFFECTS
IODINE 131
RADIOTHERAPY
THYROID
DIET
EVALUATION
INTERNAL IRRADIATION
MEDICAL SURVEILLANCE
METASTASES
PATIENTS
RADIATION DOSES
RADIONUCLIDE KINETICS
THYROIDECTOMY
THYROXINE
TRIIODOTHYRONINE
TSH
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
ENDOCRINE GLANDS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IRRADIATION
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
SURGERY
SURVEILLANCE
THERAPY
THYROID HORMONES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
551001 - Physiological Systems- Tracer Techniques