Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery
Epidemiological studies have related the incidence of mammary cancer to the dietary intake of fat and/or meat. Since organochlorine compounds (e.g., polychlorinated biphenyls (PCB) and DDT (and its metabolite DDE)) are accumulated in the adipose tissue it was tempting to suggest a relationship between levels of PCB and DDT (i.e., DDT + DDE) in breast fat tissue and the occurrence of mammary cancer. To elucidate this theory, the organochlorine levels of 14 breast fat tissue samples from breast cancer patients and similar samples from 18 decreased mammary cancer patient were compared to that of 21 similar samples from noncancer patients and finally to adipose tissue samples from 35 non-cancer autopsy specimens. No significant differences were traced. Thus it seems that the accumulation of PCB and DDT measured in breast fat tissue do not relate to the occurrence of mammary cancer.
- Research Organization:
- Roskilde Univ., Denmark
- OSTI ID:
- 6665552
- Journal Information:
- Environ. Res.; (United States), Vol. 34:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines
Organochlorine compounds in the adipose tissue of deceased persons with and without cancer: a statistical survey of some potential confounders
Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL ACCUMULATION
MAMMARY GLANDS
NEOPLASMS
ETIOLOGY
ADIPOSE TISSUE
DIET
EPIDEMIOLOGY
ANIMAL TISSUES
AROMATICS
BODY
CONNECTIVE TISSUE
DISEASES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
TISSUES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)