In situ hybridization of nucleus basalis neurons shows increased. beta. -amyloid mRNA in Alzheimer disease
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
To determine which cells within the brain produce ..beta..-amyloid mRNA and to assess expression of the ..beta..-amyloid gene in Alzheimer disease, the authors analyzed brain tissue from Alzheimer and control patients by in situ hybridization. The results demonstrate that ..beta..-amyloid mRNA is produced by neurons in the nucleus basalis of Meynert and cerebral cortex and that nuclues basalis perikarya from Alzheimer patients consistently hybridize more ..beta..-amyloid probe than those from controls. These observations support the hypothesis that increased expression of the ..beta..-amyloid gene plays an important role in the deposition of amyloid in the brains of patients with Alzheimer disease.
- Research Organization:
- Case Western Reserve Univ., Cleveland, OH (United States)
- OSTI ID:
- 6659345
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 85:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
NERVE CELLS
AUTORADIOGRAPHY
NERVOUS SYSTEM DISEASES
PATHOGENESIS
OLIGONUCLEOTIDES
HYBRIDIZATION
BRAIN
GENE REGULATION
GENES
IODINE 125
KIDNEYS
LIVER
MESSENGER-RNA
PROTEINS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RNA
SOMATIC CELLS
550201* - Biochemistry- Tracer Techniques
NERVE CELLS
AUTORADIOGRAPHY
NERVOUS SYSTEM DISEASES
PATHOGENESIS
OLIGONUCLEOTIDES
HYBRIDIZATION
BRAIN
GENE REGULATION
GENES
IODINE 125
KIDNEYS
LIVER
MESSENGER-RNA
PROTEINS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RNA
SOMATIC CELLS
550201* - Biochemistry- Tracer Techniques