skip to main content

Title: Usefulness of bone marrow imaging in childhood malignancies

Two hundred six /sup 99m/Tc sulfur colloid bone marrow scans in 110 pediatrics patients were reviewed. The normal distribution of sulfur colloid in the lower extremities in various age groups was established. There was progressive loss of uptake with increasing age from less than two years to greater than ten years. Tumor replacement was seen as regions of decreased radioactivity, and the extent of the scan defect paralleled the response of the disease to therapy. Both chemotherapy and irradiation resulted in an extension of the /sup 99m/Tc SC to peripheral marrow sites. In irradiated areas, marrow scan defects were demonstrated and generally recovered normal activity by six months after the completion of therapy. Marrow scan abnormalities caused by tumor replacement were present in four patients despite normal bone scans and radiographs. Ultimate confirmation of tumor involvement was by needle aspiration or biopsy. Persistent marrow defects were seen in two patients with neuroblastoma who had remission of their disease: biopsy revealed myelofibrosis. /sup 99m/Tc sulfur colloid bone marrow scanning is a sensitive monitor of altered marrow activity associated with pediatric hematologic or oncologic diseases.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6656615
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Pediatr.; (United States); Journal Volume: 101:2
Research Org:
Department of Pediatrics, Division of Hematology/Oncology and Radiology, James Whitcomb Riley Hospital for Children, Indianapolis, IN
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; SKELETAL DISEASES; DIAGNOSIS; SKELETON; SCINTISCANNING; TECHNETIUM 99; DIAGNOSTIC USES; AGE DEPENDENCE; CHEMOTHERAPY; ISOMERIC NUCLEI; LOCAL IRRADIATION; PATHOLOGY; PATIENTS; PEDIATRICS; RADIOCOLLOIDS; UPTAKE; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COLLOIDS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DISPERSIONS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; THERAPY; USES; YEARS LIVING RADIOISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 550901 -- Pathology-- Tracer Techniques