Scintigraphic imaging of carcinoid tumors
131-1-metaiodobenzylguanidine (131-1-MIBG) is used for scintigraphic localization and treatment of pheochromocytoma and neuroblastoma. Several other tumors, deriving from neuroectoderm (APUD tumors) may also produce catecholamines. 4 patients with surgically proven carcinoid tumors were studied by 131-1-MIBG scintigraphy. Scintigraphic images were performed with a computer assisted gamma camera 2.24, 48 and 72 hours after IV injection of 26 MBq 131-I-MIBG. In one patient single photon emission computed tomography (SPECT) with 185 Mgq 123-I-MIBG was performed additionally. Catecholamines were determined in 24-hours-urinary samples by HPLC. Serotonine was determined in plasma. Catecholamine excretion was normal in all patients, whereas serotonine was elevated in all of them. In 2 of 4 patients slight tracer uptake was observed in some of liver metastases, whereas other metastases in the liver and the primary tumor did not show 131-1-MIBG uptake. In one patient with a carcinoid tumor of the pancreas 131-1-MIBG scintigraphy and SPECT with 123-1-MIBG was positive. In one patient scintigraphy was false negative. MIBG scintigraphy is not only suitable for imaging pheochromocytoma and neuroblastoma, but may also localize carcinoid tumors and their metastases.
- Research Organization:
- Univ. Hospital, Munster
- OSTI ID:
- 6644510
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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AUTONOMIC NERVOUS SYSTEM
CARCINOMAS
SCINTISCANNING
MIBG
TISSUE DISTRIBUTION
RADIOPHARMACEUTICALS
UPTAKE
BIOLOGICAL LOCALIZATION
CAT SCANNING
COMPUTERIZED TOMOGRAPHY
GAMMA CAMERAS
IODINE 131
NEOPLASMS
RADIOIMMUNOTHERAPY
RELIABILITY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CAMERAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIOIMMUNOLOGY
RADIOISOTOPE SCANNING
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550601* - Medicine- Unsealed Radionuclides in Diagnostics