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Title: In vivo assessment of dopamine D-2 and serotonin S-2 receptors measured by C-11 N-methylspiperone (NMSP) in manic-depressive illness

Abstract

The hypothesis has been suggested that either the dopaminergic or serotonergic neurotransmitter systems may be involved in manic-depressive illness (MD). The authors have studied 16 subjects with C-11 NMSP PET imaging. Two had never received neuroleptics; 4 were drug free for 1 month at the time of scanning; of these 3 were acutely manic; the rest were on stable lithium treatment. The dopamine and serotonin binding was estimated by the 43 min. caudate/cerebellum (Ca/Cb) and frontal/cerebellum (FC/Cb) ratios, respectively. No statistically significant difference was detected when compared to 44 age and sex matched controls. Based upon the variance in the normal data and the average age of the patient group studied, the probability of detecting a difference of >30% between patients and normals is >0.8. Hence, identification of receptor abnormalities if present will be improved with increased sample size of both normals and patients.

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
The Johns Hopkins Medical Institutions, Baltimore, MD
OSTI Identifier:
6639741
Report Number(s):
CONF-850611-
Journal ID: CODEN: JNMEA
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBELLUM; POSITRON COMPUTED TOMOGRAPHY; CEREBRUM; DIAGNOSTIC USES; DOPAMINE; RADIORECEPTOR ASSAY; RECEPTORS; MENTAL DISORDERS; PATHOGENESIS; RADIOPHARMACEUTICALS; LABELLING; SEROTONIN; SPIPERONE; TISSUE DISTRIBUTION; AGE DEPENDENCE; CARBON 11; IN VIVO; LITHIUM ISOTOPES; NERVOUS SYSTEM DISEASES; PATIENTS; SEX DEPENDENCE; ALKALI METAL ISOTOPES; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBON ISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; PYRROLES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; SYMPATHOMIMETICS; TOMOGRAPHY; TRACER TECHNIQUES; TRYPTAMINES; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Wong, D F, Pearlson, G, Wagner, Jr, H N, Dannals, R F, Suneja, S, Bjorgvinsson, E, Links, J M, Ravert, H T, Wilson, A A, and Schaerf, F. In vivo assessment of dopamine D-2 and serotonin S-2 receptors measured by C-11 N-methylspiperone (NMSP) in manic-depressive illness. United States: N. p., 1985. Web.
Wong, D F, Pearlson, G, Wagner, Jr, H N, Dannals, R F, Suneja, S, Bjorgvinsson, E, Links, J M, Ravert, H T, Wilson, A A, & Schaerf, F. In vivo assessment of dopamine D-2 and serotonin S-2 receptors measured by C-11 N-methylspiperone (NMSP) in manic-depressive illness. United States.
Wong, D F, Pearlson, G, Wagner, Jr, H N, Dannals, R F, Suneja, S, Bjorgvinsson, E, Links, J M, Ravert, H T, Wilson, A A, and Schaerf, F. 1985. "In vivo assessment of dopamine D-2 and serotonin S-2 receptors measured by C-11 N-methylspiperone (NMSP) in manic-depressive illness". United States.
@article{osti_6639741,
title = {In vivo assessment of dopamine D-2 and serotonin S-2 receptors measured by C-11 N-methylspiperone (NMSP) in manic-depressive illness},
author = {Wong, D F and Pearlson, G and Wagner, Jr, H N and Dannals, R F and Suneja, S and Bjorgvinsson, E and Links, J M and Ravert, H T and Wilson, A A and Schaerf, F},
abstractNote = {The hypothesis has been suggested that either the dopaminergic or serotonergic neurotransmitter systems may be involved in manic-depressive illness (MD). The authors have studied 16 subjects with C-11 NMSP PET imaging. Two had never received neuroleptics; 4 were drug free for 1 month at the time of scanning; of these 3 were acutely manic; the rest were on stable lithium treatment. The dopamine and serotonin binding was estimated by the 43 min. caudate/cerebellum (Ca/Cb) and frontal/cerebellum (FC/Cb) ratios, respectively. No statistically significant difference was detected when compared to 44 age and sex matched controls. Based upon the variance in the normal data and the average age of the patient group studied, the probability of detecting a difference of >30% between patients and normals is >0.8. Hence, identification of receptor abnormalities if present will be improved with increased sample size of both normals and patients.},
doi = {},
url = {https://www.osti.gov/biblio/6639741}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 26:5,
place = {United States},
year = {Wed May 01 00:00:00 EDT 1985},
month = {Wed May 01 00:00:00 EDT 1985}
}

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