Inactivation of human and simian rotaviruses by chlorine dioxide

Journal Article · Tue May 01 00:00:00 EDT 1990 · Applied and Environmental Microbiology; (USA)

OSTI ID:6639166

Chen, Yu-Shiaw ^[1]; Vaughn, J M ^[2]

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1. Brookhaven National Lab., Upton, NY (USA)
2. Univ. of New England College of Medicine, Biddeford, ME (USA)

The inactivation of single-particle stocks of human (type 2, Wa) and simian (SA-11) rotaviruses by chlorine dioxide was investigated. Experiments were conducted at 4{degree}C in a standard phosphate-carbonate buffer. Both virus types were rapidly inactivated, within 20 s under alkaline conditions, when chlorine dioxide concentrations ranging from 0.05 to 0.2 mg/liter were used. Similar reductions of 10{sup 5}-fold in infectivity required additional exposure time of 120 s at 0.2 mg/liter for Wa and at 0.5 mg/liter for SA-11, respectively, at pH 6.0. The inactivation of both virus types was moderate a neutral pH, and the sensitivities to chlorine dioxide were similar. The observed enhancement of virucidal efficiency with increasing pH was contrary to earlier findings with chlorine- and ozone-treated rotavirus particles, where efficiencies decreased with increasing alkalinity. Comparison of 99.9% virus inactivation times revealed ozone to be the most effective virucidal agent among these three disinfectants.

• OSTI ID: 6639166
• Journal Information: Applied and Environmental Microbiology; (USA), Vol. 56:5; ISSN 0099-2240
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINE OXIDES
TOXICITY
VIRUSES
INACTIVATION
CHLORINE
COMPARATIVE EVALUATIONS
MAN
MONKEYS
OZONE
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ANIMALS
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ELEMENTS
HALOGEN COMPOUNDS
HALOGENS
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NONMETALS
OXIDES
OXYGEN COMPOUNDS
PARASITES
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