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Title: [Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, July 1, 1991--June 1, 1992

The primary goal of this program is to achieve a more thorough understanding of the mechanisms employed by higher organisms to resist DNA damage. Concurrently this effort contributes to an improved understanding of the processes of mutagenesis and carcinogenesis in higher eukaryotes. Drosophila was initially chosen as a model organism for investigating functions that control mutagen resistance because of the ease with which one can isolate and characterize mutagen-sensitive mutants in this multicellular organism. This laboratory then went on to investigate the DNA repair defects of such mutants while others performed complementary genetic and cytogenetic studies which relate DNA repair processes to mutagenesis and chromosome stability. Currently, recombinant DNA technology is being employed to investigate the mechanisms of mutagen resistance defined by those mutants. The following two studies experienced the most significant progress during the past year: cloning and genetic characterization of the mus209 gene, and genetic and molecular analysis of the mus308 gene.
Publication Date:
OSTI Identifier:
663538
Report Number(s):
DOE/ER/60538-T5
ON: DE98007384; BR: HA0202020;KP0402000; TRN: AHC29818%%375
DOE Contract Number:
FG03-87ER60538
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: [1992]
Research Org:
Univ. of California, Davis, CA (United States)
Sponsoring Org:
USDOE Office of Energy Research, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; PROGRESS REPORT; STRAND BREAKS; DNA REPAIR; MUTAGENESIS; DROSOPHILA; DNA-CLONING; GENES; CARCINOGENESIS; RECOMBINANT DNA