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Title: [Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, June 1, 1989--September 1, 1990

The most exciting discovery made over the past year derives from an analysis of the interaction between DNA repair and P-element transposition. A powerful new system was developed for analyzing the repair of DNA double-strand breaks. A screen was completed of mutagenized autosomes obtained from two San Francisco laboratories with the recovery of several mutants that will provide the foundation for future efforts to clone repair related genes. At the same time, strong progress has been made in the cloning and characterization of the repair-related genes mei-41 and mus209. Finally, the efforts to clone the mei-9 gene have uncovered the existence of a unsuspected feature of the system used for transposon-tagging in Drosophila. This new knowledge will aid future cloning efforts as well as those of others in the field.
Publication Date:
OSTI Identifier:
663536
Report Number(s):
DOE/ER/60538-T4
ON: DE98007382; TRN: AHC29818%%373
DOE Contract Number:
FG03-87ER60538
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: [1990]
Research Org:
Univ. of California, Davis, CA (United States)
Sponsoring Org:
USDOE Office of Energy Research, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; PROGRESS REPORT; STRAND BREAKS; DNA REPAIR; TRANSPOSONS; GENETIC EFFECTS; GENE MUTATIONS; DROSOPHILA; DNA-CLONING; GENES