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Title: Cutaneous mast cell maturation does not depend on an intact bone marrow microenvironment

A study was made to determine whether the maturation of murine cutaneous mast cells from stem cells depends on an intact bone marrow microenvironment. Normal bone marrow cells (+/+) were infused into 2 groups of mast cell-deficient mice: WBB6F1-W/Wv mice and /sup 89/Sr-pretreated W/Wv mice. /sup 89/Sr is a long-lived bone-seeking radioisotope which provides continuous irradiation of the marrow and thereby ablates the marrow microenvironment. Skin biopsies revealed that the /sup 89/Sr-pretreated mice and the controls had repopulated their skin with mast cells equally well. Natural killer cell function was significantly depressed in the /sup 89/Sr-treated mice, confirming that the marrow microenvironment had been functionally altered. It appears that, although the precursors for cutaneous mast cells are marrow derived, they do not need an intact marrow microenvironment for maturation.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
6628610
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Invest. Dermatol.; (United States); Journal Volume: 82:1
Research Org:
Univ. of Texas Health Science Center, Dallas
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; INTERNAL IRRADIATION; MAST CELLS; CELL DIFFERENTIATION; ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; CYTOLOGY; MICE; SKIN; STEM CELLS; STRONTIUM 89; ALKALINE EARTH ISOTOPES; ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGY; BODY; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; HEMATOPOIETIC SYSTEM; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOTOPES; MAMMALS; NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; STRONTIUM ISOTOPES; TISSUES; VERTEBRATES 560162* -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells