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Title: Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol

Abstract

With the introduction of radiolabeled catecholamine analogues, the noninvasive evaluation of the cardiac sympathetic nervous system has become possible. This study evaluated the effect of regional ischemia on myocardial retention of the new norepinephrine analogue 6-({sup 18}F) fluorometaraminol (FMR) in the open chest dog model. Six dogs were injected intravenously with FMR following 30-min occlusion of the left anterior descending artery. Six sham animals served as control group. Regional myocardial blood flow as determined by microspheres decreased 87% during ischemia (p less than 0.01), but was not significantly different from control myocardium following reperfusion. Regional myocardial 18F activity as determined postmortem was significantly reduced in reperfused myocardium (-34%), which paralleled an 18% reduction of tissue norepinephrine concentration. Thus, short time periods of coronary occlusion affect neuronal function indicating the sensitivity of the sympathetic nerve terminals to ischemia. FMR provides a new tracer approach for the characterization of neuronal integrity in postischemic myocardium.

Authors:
; ; ; ; ; ;  [1]
  1. Univ. of Michigan Medical Center, Ann Arbor (USA)
Publication Date:
OSTI Identifier:
6620365
Resource Type:
Journal Article
Journal Name:
Journal of Nuclear Medicine; (USA)
Additional Journal Information:
Journal Volume: 31:8; Journal ID: ISSN 0161-5505
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AUTONOMIC NERVOUS SYSTEM; SENSITIVITY; MYOCARDIUM; BLOOD FLOW; RADIOPHARMACEUTICALS; RETENTION; DOGS; FLUORINE 18; HEART; INTRAVENOUS INJECTION; ISCHEMIA; METABOLISM; MICROSPHERES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASES; DRUGS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; INJECTION; INTAKE; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MUSCLES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; VASCULAR DISEASES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Schwaiger, M, Guibourg, H, Rosenspire, K, McClanahan, T, Gallagher, K, Hutchins, G, and Wieland, D M. Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol. United States: N. p., 1990. Web.
Schwaiger, M, Guibourg, H, Rosenspire, K, McClanahan, T, Gallagher, K, Hutchins, G, & Wieland, D M. Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol. United States.
Schwaiger, M, Guibourg, H, Rosenspire, K, McClanahan, T, Gallagher, K, Hutchins, G, and Wieland, D M. 1990. "Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol". United States.
@article{osti_6620365,
title = {Effect of regional myocardial ischemia on sympathetic nervous system as assessed by fluorine-18-metaraminol},
author = {Schwaiger, M and Guibourg, H and Rosenspire, K and McClanahan, T and Gallagher, K and Hutchins, G and Wieland, D M},
abstractNote = {With the introduction of radiolabeled catecholamine analogues, the noninvasive evaluation of the cardiac sympathetic nervous system has become possible. This study evaluated the effect of regional ischemia on myocardial retention of the new norepinephrine analogue 6-({sup 18}F) fluorometaraminol (FMR) in the open chest dog model. Six dogs were injected intravenously with FMR following 30-min occlusion of the left anterior descending artery. Six sham animals served as control group. Regional myocardial blood flow as determined by microspheres decreased 87% during ischemia (p less than 0.01), but was not significantly different from control myocardium following reperfusion. Regional myocardial 18F activity as determined postmortem was significantly reduced in reperfused myocardium (-34%), which paralleled an 18% reduction of tissue norepinephrine concentration. Thus, short time periods of coronary occlusion affect neuronal function indicating the sensitivity of the sympathetic nerve terminals to ischemia. FMR provides a new tracer approach for the characterization of neuronal integrity in postischemic myocardium.},
doi = {},
url = {https://www.osti.gov/biblio/6620365}, journal = {Journal of Nuclear Medicine; (USA)},
issn = {0161-5505},
number = ,
volume = 31:8,
place = {United States},
year = {Wed Aug 01 00:00:00 EDT 1990},
month = {Wed Aug 01 00:00:00 EDT 1990}
}