Organ transplantation in mongrel dogs using total lymphoid irradiation (TLI)

Conference · Sun Mar 01 00:00:00 EST 1981 · Transplant. Soc., Int. Cong., Proc.; (United States)

OSTI ID:6619680

Koretz, S H; Gottlieb, M S; Strober, S; Pennock, J; Bieber, C P; Hoppe, R T; Reitz, B A; Kaplan, H S

Although we were able to establish bone marrow chimerism in mongrel dogs using TLI at a cumulative dose of 1800 rad, it was more difficult to establish prolonged organ allograft survival in this system. We review here our experience with allogeneic heart transplantation in dogs using TLI combined with limited courses of pharmacologic immunosuppression, an approach that appears to hold considerable promise for clinical organ transplantation.

• Research Organization: Stanford Univ. School of Medicine, CA
• OSTI ID: 6619680
• Journal Information: Transplant. Soc., Int. Cong., Proc.; (United States), Vol. 13:1; Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 29 Jun 1980
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
EVALUATION
GLOBULINS
HEART
TRANSPLANTS
IMMUNITY
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
METHOTREXATE
PARTIAL BODY IRRADIATION
DOGS
FRACTIONATED IRRADIATION
GRAFT-HOST REACTION
LYMPH NODES
RADIATION CHIMERAS
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CHIMERAS
CONNECTIVE TISSUE CELLS
DRUGS
EXTERNAL IRRADIATION
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MOSAICISM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals