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Title: Gene transcription and electromagnetic fields

Our overall aim is to obtain sufficient information to allow us to ultimately determine whether ELF EM field exposure is an initiating factor in neoplastic transformation and/or if exposure can mimic characteristics of the second-step counterpart in neoplastic disease. This aim is based on our previous findings that levels of some transcripts are increased in cells exposed to EM fields. While the research is basic in nature, the ramifications have bearing on the general safety of exposure to EM fields in industrial and everyday life. A large array of diverse biological effects are reported to occur as the result of exposure to elf EM fields, suggesting that the cell response to EM fields is at a basic level, presumably initiated by molecular and/or biophysical events at the cell membrane. The hypothesized route is a signal transduction pathway involving membrane calcium fluxes. Information flow resulting from signal transduction can mediate the induction of regulatory factors in the cell, and directly affect how transcription is regulated.
Authors:
Publication Date:
OSTI Identifier:
6615856
Report Number(s):
DOE/CE/34023-T1
ON: DE93010854
DOE Contract Number:
FG01-89CE34023
Resource Type:
Technical Report
Research Org:
Hunter Coll., New York, NY (United States)
Sponsoring Org:
DOE; USDOE, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ELECTRIC FIELDS; CARCINOGENESIS; MAGNETIC FIELDS; CELL CULTURES; ENZYME INDUCTION; GENE REGULATION; PROGRESS REPORT; DOCUMENT TYPES; PATHOGENESIS 560400* -- Other Environmental Pollutant Effects; 550200 -- Biochemistry