Effect of ozone on the postnatal development of lamb mucociliary apparatus
- Univ. of Miami, Miami Beach, FL (USA)
We determined whether exposure to O3 early in the postnatal period impairs the normal development of the mucociliary apparatus in lambs and whether such changes lead to prolonged abnormalities in mucociliary function. Lambs were exposed to air (controls) or to 1 ppm O3 for 4 h/day for 5 days during the 1st wk of life. Tracheal mucus velocity (TMV), a marker of lung mucociliary clearance, was measured in vivo at birth (0 wk) and up to 24 wk later, and tracheal secretory function was measured (in vitro) and the morphology of the tracheal mucosa was determined at 0 and 2 wk in both groups. In the control group, TMV increased 94% from 0 to 2 wk (P less than 0.05), continued to increase until reaching a plateau at 8 wk, and then remained constant from 8 to 24 wk. In contrast, O3-exposed lambs showed a 24% decrease in TMV from 0 to 2 wk (P less than 0.05 vs. control), and throughout the remaining time TMV remained below (P less than 0.05) that observed in control lambs. O3 exposure partially prevented the age-dependent decrease in basal secretion of tracheal macromolecules normally observed between 0 and 2 wk. These changes in secretory function were associated with a significant increase in tissue conductance (37%, P less than 0.05 vs. 0 wk), predominantly the result of active chloride secretion. The functional changes induced by O3 were associated with a retardation of the normal morphological development of the tracheal epithelium.
- OSTI ID:
- 6613804
- Journal Information:
- Journal of Applied Physiology (1985); (USA), Vol. 68:6; ISSN 8750-7587
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
OZONE
TOXICITY
AGE DEPENDENCE
LUNG CLEARANCE
METABOLISM
MUCOUS MEMBRANES
SHEEP
THREONINE
TRACHEA
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
CLEARANCE
DOMESTIC ANIMALS
EXCRETION
HYDROXY ACIDS
MAMMALS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
RESPIRATORY SYSTEM
RUMINANTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology