Inhalation developmental toxicology studies: Teratology study of acetone in mice and rats: Final report
Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 440, 2200, or 11000 ppm, and in Swiss (CD-1) mice exposed to 0, 440, 2200, and 6600 ppm acetone vapors, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and approx.32 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 46 refs., 6 figs., 27 tabs.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6608305
- Report Number(s):
- PNL-6768; ON: DE89005671
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACETONE
TOXICITY
RATS
MORTALITY
COMPARATIVE EVALUATIONS
CONGENITAL MALFORMATIONS
DOSE-RESPONSE RELATIONSHIPS
INHALATION
LIFE SPAN
LITTER SIZE
MICE
PRENATAL EXPOSURE
PROGRESS REPORT
SEX DEPENDENCE
TERATOGENESIS
TIME DEPENDENCE
VOLATILE MATTER
ANIMALS
DOCUMENT TYPES
INTAKE
KETONES
MALFORMATIONS
MAMMALS
MATTER
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology