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Title: Inhalation developmental toxicology studies: Teratology study of acetone in mice and rats: Final report

Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 440, 2200, or 11000 ppm, and in Swiss (CD-1) mice exposed to 0, 440, 2200, and 6600 ppm acetone vapors, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and approx.32 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 46 refs., 6 figs., 27 tabs.
Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
6608305
Report Number(s):
PNL-6768
ON: DE89005671
DOE Contract Number:
AC06-76RL01830
Resource Type:
Technical Report
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Research Org:
Pacific Northwest Lab., Richland, WA (USA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ACETONE; TOXICITY; RATS; MORTALITY; COMPARATIVE EVALUATIONS; CONGENITAL MALFORMATIONS; DOSE-RESPONSE RELATIONSHIPS; INHALATION; LIFE SPAN; LITTER SIZE; MICE; PRENATAL EXPOSURE; PROGRESS REPORT; SEX DEPENDENCE; TERATOGENESIS; TIME DEPENDENCE; VOLATILE MATTER; ANIMALS; DOCUMENT TYPES; INTAKE; KETONES; MALFORMATIONS; MAMMALS; MATTER; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; RODENTS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology