In vivo assessment of dopamine and serotonin receptors measured by C-11 n-methylspiperone (NMSP) in patients with schizophrenia

Wong, D F; Tune, L E; Wagner, Jr, H N; Suneja, S; Bjorvinsson, E; Pearlson, G; Dannals, R F; Ravert, H T; Wilson, A A; Links, J M

Title: In vivo assessment of dopamine and serotonin receptors measured by C-11 n-methylspiperone (NMSP) in patients with schizophrenia

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Abstract

The authors carried out PET imaging with C-11 NMSP in 13 pts. diagnosed as chronic schizophrenic by (DSM 3) criteria. They had no detectable serum neuroleptics by radioassay at the time of the scan. No pt. had received a neuroleptic for at least 1 week before study, with an avg. abstinence of 7 mo. One had never been on neuroleptics. During the time of scanning, 8/13 had delusions and hallucinations. There was no statistically significant difference from 44 age and sex matched control subjects for the 43 min. Caudate/cerebellar ratio, or the Frontal/Cerebellar ratio, both measures of relative dopamine D2, and serotonin S2 binding. These preliminary studies suggest that these drug free pts. show no large differences in the receptor levels compared to normal data. Differences from in vitro data could be due to: differences in duration of illness (the avg. 10.3) yrs.; difference in age (our pts. vg. 32.7 are much younger than those dying with schizophrenia); drug induced effects at death or persistent neuroleptic effect in our pts.; or difference in method.

Authors:: Wong, D F; Tune, L E; Wagner, Jr, H N; Suneja, S; Bjorvinsson, E; Pearlson, G; Dannals, R F; Ravert, H T; Wilson, A A; Links, J M

Publication Date:: Wed May 01 00:00:00 EDT 1985

Research Org.:: The Johns Hopkins Medical Institutions, Baltimore, MD

OSTI Identifier:: 6605195

Report Number(s):: CONF-850611-
Journal ID: CODEN: JNMEA

Resource Type:: Conference

Journal Name:: J. Nucl. Med.; (United States)

Additional Journal Information:: Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBELLUM; POSITRON COMPUTED TOMOGRAPHY; CEREBRUM; DOPAMINE; RECEPTORS; MENTAL DISORDERS; DIAGNOSIS; PATHOGENESIS; SEROTONIN; SPIPERONE; RADIOISOTOPE SCANNING; AGE DEPENDENCE; BEHAVIOR; CARBON 11; IN VITRO; IN VIVO; NEUROLOGY; PATIENTS; PERFORMANCE; RADIOPHARMACEUTICALS; RADIORECEPTOR ASSAY; SEX DEPENDENCE; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBON ISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MEDICINE; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; PYRROLES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; SYMPATHOMIMETICS; TOMOGRAPHY; TRACER TECHNIQUES; TRYPTAMINES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550602 - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats


                    Wong, D F, Tune, L E, Wagner, Jr, H N, Suneja, S, Bjorvinsson, E, Pearlson, G, Dannals, R F, Ravert, H T, Wilson, A A, and Links, J M. In vivo assessment of dopamine and serotonin receptors measured by C-11 n-methylspiperone (NMSP) in patients with schizophrenia.  United States: N. p., 1985. 
        Web.

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                    Wong, D F, Tune, L E, Wagner, Jr, H N, Suneja, S, Bjorvinsson, E, Pearlson, G, Dannals, R F, Ravert, H T, Wilson, A A, & Links, J M. In vivo assessment of dopamine and serotonin receptors measured by C-11 n-methylspiperone (NMSP) in patients with schizophrenia.  United States.

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                    Wong, D F, Tune, L E, Wagner, Jr, H N, Suneja, S, Bjorvinsson, E, Pearlson, G, Dannals, R F, Ravert, H T, Wilson, A A, and Links, J M. 1985.  
        "In vivo assessment of dopamine and serotonin receptors measured by C-11 n-methylspiperone (NMSP) in patients with schizophrenia".  United States.

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@article{osti_6605195,

  title        = {In vivo assessment of dopamine and serotonin receptors measured by C-11 n-methylspiperone (NMSP) in patients with schizophrenia},

  author       = {Wong, D F and Tune, L E and Wagner, Jr, H N and Suneja, S and Bjorvinsson, E and Pearlson, G and Dannals, R F and Ravert, H T and Wilson, A A and Links, J M},

  abstractNote = {The authors carried out PET imaging with C-11 NMSP in 13 pts. diagnosed as chronic schizophrenic by (DSM 3) criteria. They had no detectable serum neuroleptics by radioassay at the time of the scan. No pt. had received a neuroleptic for at least 1 week before study, with an avg. abstinence of 7 mo. One had never been on neuroleptics. During the time of scanning, 8/13 had delusions and hallucinations. There was no statistically significant difference from 44 age and sex matched control subjects for the 43 min. Caudate/cerebellar ratio, or the Frontal/Cerebellar ratio, both measures of relative dopamine D2, and serotonin S2 binding. These preliminary studies suggest that these drug free pts. show no large differences in the receptor levels compared to normal data. Differences from in vitro data could be due to: differences in duration of illness (the avg. 10.3) yrs.; difference in age (our pts. vg. 32.7 are much younger than those dying with schizophrenia); drug induced effects at death or persistent neuroleptic effect in our pts.; or difference in method.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6605195},
  journal      = {J. Nucl. Med.; (United States)},
number       = ,

  volume       = 26:5,

  place        = {United States},

  year         = {Wed May 01 00:00:00 EDT 1985},

  month        = {Wed May 01 00:00:00 EDT 1985}

}

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