Suppression of newborn natural killer cell activity by prostaglandin E2

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Am. J. Obstet. Gynecol.; (United States)

DOI:https://doi.org/10.1016/S0002-9378(88)80164-9· OSTI ID:6600279

Milch, P O; Salvatore, W; Luft, B; Baker, D A

The effect of prostaglandin E2 on natural killer cell activity of cord blood was examined. Natural killer cell activity, determined by chromium 51 release, was significantly reduced after prostaglandin E2 (1 microgram/ml) treatment. Prostaglandin E2 has been found to enhance the cellular spread of herpesvirus. Thus prostaglandins may enhance viral infections indirectly by suppressing natural killer cell activity.

• Research Organization: State Univ. of New York, Stony Brook (USA)
• OSTI ID: 6600279
• Journal Information: Am. J. Obstet. Gynecol.; (United States), Vol. 159:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HERPES SIMPLEX
IMMUNOSUPPRESSION
PROSTAGLANDINS
BIOLOGICAL FUNCTIONS
BLOOD
CELL KILLING
CHROMIUM 51
FETUSES
IN VITRO
PROGESTERONE
TRACER TECHNIQUES
VIRUSES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY FLUIDS
CHROMIUM ISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
HORMONES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
MATERIALS
MICROORGANISMS
NUCLEI
ORGANIC COMPOUNDS
PARASITES
PREGNANES
RADIOISOTOPES
SKIN DISEASES
STEROID HORMONES
STEROIDS
VIRAL DISEASES
550901* - Pathology- Tracer Techniques