Chelatable lead body burden (by calcium-disodium EDTA) and blood lead concentration in man
The chelatable part of lead body burden was measured in 32 workers and seven office workers after an infusion test with CaNa/sub 2/EDTA. The workers had been exposed to lead at a lead and zinc processing unit for one to three years (mean one year). There was good correlation (r = 0.87) between blood lead and chelatable urinary lead excretion described by the equation y = 0 07.10/sup 0.46 x/. From this equation it can be predicted that the generally accepted limit value for chelatable urinary lead excretion, 0.42 ..mu..mol/mmol CaNa/sub 2/EDTA administered per 24 hours (3.1 ..mu..mol/24 hours or 650 ..mu..g/24 hours), corresponds to a blood lead concentration (PbB) of 1.7 ..mu..mol/l (or 35 ..mu..g/100 ml), which is lower than the commonly accepted limit value of 2.9 ..mu..mol/1 (or 60..mu..g/100 ml) for occupationally lead-exposed persons. There was a better correlation between the chelatable lead excretion and the urinary ALA-excretion (r = 0.45; p < 0.001) than between PbB and the urinary ALA-excretion (r = 0.26; p > 0.05).
- Research Organization:
- Univ. of Copenhagen, Denmark
- OSTI ID:
- 6597034
- Journal Information:
- J. Occup. Med.; (United States), Vol. 23:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BODY BURDEN
MEASURING METHODS
LEAD
BLOOD
CHELATES
CHRONIC EXPOSURE
CORRELATIONS
EDTA
EXCRETION
EXPERIMENTAL DATA
MAN
URINE
AMINO ACIDS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPLEXES
DATA
ELEMENTS
INFORMATION
MAMMALS
MATERIALS
METALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
VERTEBRATES
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)