Quaternary naltrexone reverses radiogenic and morphine-induced locomotor hyperactivity
The present study attempted to determine the relative role of the peripheral and central nervous system in the production of morphine-induced or radiation-induced locomotor hyperactivity of the mouse. Toward this end, we used a quaternary derivative of an opiate antagonist (naltrexone methobromide), which presumably does not cross the blood-brain barrier. Quaternary naltrexone was used to challenge the stereotypic locomotor response observed in these mice after either an i.p. injection of morphine or exposure to 1500 rads /sup 60/Co. The quaternary derivative of naltrexone reversed the locomotor hyperactivity normally observed in the C57BL/6J mouse after an injection of morphine. It also significantly attenuated radiation-induced locomotion. The data reported here support the hypothesis of endorphin involvement in radiation-induced and radiogenic behaviors. However, these conclusions are contingent upon further research which more fully evaluates naltrexone methobromide's capacity to cross the blood-brain barrier.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 6596475
- Report Number(s):
- AD-P-003252/4
- Resource Relation:
- Other Information: This article is from 'Proceedings of the Symposium: Psychology in the Department of Defense (9th) Held at Colorado Springs, Colorado on 18-20 April 1984', AD-A141043, p77-81
- Country of Publication:
- United States
- Language:
- English
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