Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats

Journal Article · Sun Feb 01 00:00:00 EST 1987 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.165.2.566· OSTI ID:6596435

Dallman, M J; Wood, K J; Morris, P J

Preoperative, donor-specific blood transfusion leads to indefinite survival of rat renal allografts in the strain combinations used. /sup 51/Cr-release assays have shown that the level of specific cytotoxic effector activity in the grafts of transfused (nonrejected kidney) animals is very high and may equal or exceed that seen in the grafts of untreated (rejected kidney) recipients. Such cytotoxicity demonstrates specificity for the alloantigens of the kidney, is T cell-mediated, and may persist within the transplant.

• Research Organization: Univ. of Oxford, England
• OSTI ID: 6596435
• Journal Information: J. Exp. Med.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BLOOD
TRANSFUSIONS
KIDNEYS
TRANSPLANTS
CHROMIUM 51
GRAFT-HOST REACTION
LYMPHOCYTES
RATS
SURVIVAL CURVES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY
BODY FLUIDS
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
LEUKOCYTES
MAMMALS
MATERIALS
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
THERAPY
VERTEBRATES
550600* - Medicine
551001 - Physiological Systems- Tracer Techniques