Reduced cerebral glucose metabolism and increased brain capillary permeability following high-dose methotrexate chemotherapy: a positron emission tomographic study
Regional glucose metabolic rate constants and blood-to-brain transport of rubidium were estimated using positron emission tomography in an adolescent patient with a brain tumor, before and after chemotherapy with intravenous high-dose methotrexate. Widespread depression of cerebral glucose metabolism was apparent 24 hours after drug administration, which may reflect reduced glucose phosphorylation, and the influx rate constant for /sup 82/Rb was increased, indicating a drug-induced alteration in blood-brain barrier function. Associated changes in neuropsychological performance, electroencephalogram, and plasma amino acid concentration were identified in the absence of evidence of systemic methotrexate toxicity, suggesting primary methotrexate neurotoxicity.
- Research Organization:
- Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 6592611
- Journal Information:
- Ann. Neurol.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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BRAIN
NEOPLASMS
POSITRON COMPUTED TOMOGRAPHY
CAPILLARIES
PERMEABILITY
GLUCOSE
METABOLISM
CHEMOTHERAPY
ADOLESCENTS
BLOOD-BRAIN BARRIER
MEMBRANE TRANSPORT
METHOTREXATE
PATIENTS
RUBIDIUM 82
AGE GROUPS
ALDEHYDES
ALKALI METAL ISOTOPES
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEXOSES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
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RUBIDIUM ISOTOPES
SACCHARIDES
THERAPY
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550600 - Medicine