Total lymphatic irradiation and bone marrow in human heart transplantation

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Ann. Thorac. Surg.; (United States)

DOI:https://doi.org/10.1016/S0003-4975(10)62227-8· OSTI ID:6589882

Kahn, D R; Hong, R; Greenberg, A J; Gilbert, E F; Dacumos, G C; Dufek, J H

Six patients, aged 36 to 59 years, had heart transplants for terminal myocardial disease using total lymphatic irradiation (TLI) and donor bone marrow in addition to conventional therapy. All patients were poor candidates for transplantation because of marked pulmonary hypertension, unacceptable tissue matching, or age. Two patients are living and well more than four years after the transplants. Two patients died of infection at six and seven weeks with normal hearts. One patient, whose preoperative pulmonary hypertension was too great for an orthotopic heart transplant, died at 10 days after such a procedure. The other patient died of chronic rejection seven months postoperatively. Donor-specific tolerance developed in 2 patients. TLI and donor bone marrow can produce specific tolerance to donor antigens and allow easy control of rejection, but infection is still a major problem. We describe a new technique of administering TLI with early reduction of prednisone that may help this problem.

• Research Organization: The Baptist Medical Center-Princeton, Birmingham, AL
• OSTI ID: 6589882
• Journal Information: Ann. Thorac. Surg.; (United States), Vol. 38:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
IMMUNOSUPPRESSION
HEART
TRANSPLANTS
LYMPHATIC SYSTEM
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
PATIENTS
RADIOIMMUNOLOGY
ANIMAL TISSUES
BODY
CARDIOVASCULAR SYSTEM
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
IRRADIATION
ORGANS
TISSUES
560151* - Radiation Effects on Animals- Man