Developing improved strategies to determine male reproductive risk from environmental toxins

Technical Report · Wed Jan 01 00:00:00 EST 1992

OSTI ID:6587539

Berndtson, W E; Clegg, E D

It is important that evaluation procedures for chemicals incorporate measures suitable to detect a wide range of potential effects from those chemicals. The reproductive systems are among the most sensitive to toxic insult, so it is important that effective methods be developed and applied for detection of reproductive effects and protection of reproductive capability. As adequate data on the effects of human exposures are seldom available, it is necessary then to use data from other species. Species used most frequently are rodents, rabbits, dogs and subhuman primates. Knowledge gained from research with farm species is being applied in the design of improved protocols to detect health effects. Included are important contributions in developing new evaluation tests, improved experimental design and in furthering understanding of reproductive biology. The paper addresses several testing and risk assessment issues in male reproductive toxicology that form the basis for some of the authors' research.

• Research Organization: Environmental Protection Agency, Washington, DC (United States). Reproductive and Developmental Toxicology Branch
• OSTI ID: 6587539
• Report Number(s): PB-93-167286/XAB; EPA-600/J-93/047
• Resource Relation: Other Information: Pub. in Theriogenology 38, 223-237(1992)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
TOXICITY
RESEARCH PROGRAMS
TOXINS
RISK ASSESSMENT
ANIMALS
BIOLOGY
DESIGN
DETECTION
DOGS
EVALUATION
HISTOLOGY
POLLUTANTS
PRIMATES
RABBITS
REPRODUCTION
RODENTS
SPERMATOZOA
TESTING
ANTIGENS
GAMETES
GERM CELLS
HAZARDOUS MATERIALS
MAMMALS
MATERIALS
TOXIC MATERIALS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology