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Title: Inborn anemias in mice: (Annual report, 1980-1981)

The basic purpose of this study is the delineation and exploitation of inborn anemias of the laboratory mouse, carried out by utilization of genetically homogeneous stocks segregating only for anemia-producing genes; by physiological and histological descriptions of each condition at all stages in the life history; by determination of tissue sites of primary gene action through tissue culture studies, tissue transplantation and parabiosis experiments; by analysis of reactions of normal and anemic mice to a variety of stressful stimuli, including x-irradiation, hypoxia, and toxic chemicals, and by biochemical comparisons between tissues, especially erythrocytes and hemopoietic cells of normal vs each type of anemic mouse. At present 16 single-locus anemias are known in the mouse, plus one with multifactorial inheritance (the autoimmune hemolytic anemia of NZB inbred mice). Of these, six are maintained only by the Jackson Laboratory, and two others have but one additional source. Effects of anemia-producing mutant alleles of these loci (an; f; ja; ha; Hba/sup th/; mk; nb; Sl and Sl/sup d/; sla; sph; and W, W/sup v/, W/sup J/ and 10 other putative W-alleles) are currently under investigation at the Jackson Laboratory. 15 refs.
Authors:
Publication Date:
OSTI Identifier:
6586573
Report Number(s):
DOE/EV/03264-T5
ON: DE87010460
DOE Contract Number:
AC02-76EV03264
Resource Type:
Technical Report
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Research Org:
Jackson Lab., Bar Harbor, ME (USA)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANEMIAS; BIOLOGICAL MODELS; HEREDITARY DISEASES; MICE; ANIMALS; DISEASES; HEMIC DISEASES; MAMMALS; RODENTS; SYMPTOMS; VERTEBRATES 550900* -- Pathology; 550400 -- Genetics