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Title: Imaging the primate adrenal medulla with (/sup 123/I) and (/sup 131/I) metaiodobenzylguanidine: concise communication

Abstract

An evaluation of radioiodinated meta-iodobenzylguanidine (m-IBG) as an adrenomedullary imaging agent is reported in 15 rhesus monkeys. Scintiscans of the monkey adrenal medulla have been obtained with (/sup 123/I)- and (m-/sup 131/)IBG at 2 to 6 days after injection. The imaging superiority of m-IBG over its positional isomer, para-iodobenzylguanidine (p-IBG), is documented in both dogs and monkeys. Administration of reserpine, a depletor of catecholamine stores, markedly lowers the (m-/sup 131/I)-IBG content of the dog adrenal medulla, but the adrenergic blocking agents phenoxybenzamine and propanolol have no effect. Subcellular fractionation of the dog's adrenal medullae reveals that m-IBG is sequestered mainly in the chromaffin storage granules. The results of this study suggest that radioiodinated m-IBG, previously reported to image the primate myocardium, also merits evaluation as a clinical radiopharmaceutical for the adrenal medulla.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of Michigan, Ann Arbor
OSTI Identifier:
6582513
DOE Contract Number:  
EY-76-S-02-2031
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 22:4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ADRENAL GLANDS; SCINTISCANNING; IODINE 123; DIAGNOSTIC USES; IODINE 131; BIOLOGICAL PATHWAYS; COMPARATIVE EVALUATIONS; DOGS; GUANIDINES; IMAGES; MACACUS; PERFORMANCE TESTING; RADIONUCLIDE KINETICS; RESPONSE MODIFYING FACTORS; TISSUE DISTRIBUTION; UPTAKE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; MONKEYS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; RADIOISOTOPE SCANNING; RADIOISOTOPES; TESTING; USES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Wieland, D M, Brown, L E, Tobes, M C, Rogers, W L, Marsh, D D, Mangner, T J, Swanson, D P, and Beierwaltes, W H. Imaging the primate adrenal medulla with (/sup 123/I) and (/sup 131/I) metaiodobenzylguanidine: concise communication. United States: N. p., 1981. Web.
Wieland, D M, Brown, L E, Tobes, M C, Rogers, W L, Marsh, D D, Mangner, T J, Swanson, D P, & Beierwaltes, W H. Imaging the primate adrenal medulla with (/sup 123/I) and (/sup 131/I) metaiodobenzylguanidine: concise communication. United States.
Wieland, D M, Brown, L E, Tobes, M C, Rogers, W L, Marsh, D D, Mangner, T J, Swanson, D P, and Beierwaltes, W H. 1981. "Imaging the primate adrenal medulla with (/sup 123/I) and (/sup 131/I) metaiodobenzylguanidine: concise communication". United States.
@article{osti_6582513,
title = {Imaging the primate adrenal medulla with (/sup 123/I) and (/sup 131/I) metaiodobenzylguanidine: concise communication},
author = {Wieland, D M and Brown, L E and Tobes, M C and Rogers, W L and Marsh, D D and Mangner, T J and Swanson, D P and Beierwaltes, W H},
abstractNote = {An evaluation of radioiodinated meta-iodobenzylguanidine (m-IBG) as an adrenomedullary imaging agent is reported in 15 rhesus monkeys. Scintiscans of the monkey adrenal medulla have been obtained with (/sup 123/I)- and (m-/sup 131/)IBG at 2 to 6 days after injection. The imaging superiority of m-IBG over its positional isomer, para-iodobenzylguanidine (p-IBG), is documented in both dogs and monkeys. Administration of reserpine, a depletor of catecholamine stores, markedly lowers the (m-/sup 131/I)-IBG content of the dog adrenal medulla, but the adrenergic blocking agents phenoxybenzamine and propanolol have no effect. Subcellular fractionation of the dog's adrenal medullae reveals that m-IBG is sequestered mainly in the chromaffin storage granules. The results of this study suggest that radioiodinated m-IBG, previously reported to image the primate myocardium, also merits evaluation as a clinical radiopharmaceutical for the adrenal medulla.},
doi = {},
url = {https://www.osti.gov/biblio/6582513}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 22:4,
place = {United States},
year = {Wed Apr 01 00:00:00 EST 1981},
month = {Wed Apr 01 00:00:00 EST 1981}
}