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Title: The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens

Abstract

The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied. It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen. The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation. A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent. This suggests that DNA crosslink lesions may play a rle in sunburn cell production.

Authors:
;
Publication Date:
Research Org.:
Department of Photobiology, Institute of Dermatology, London, England
OSTI Identifier:
6561869
Resource Type:
Journal Article
Journal Name:
J. Invest. Dermatol.; (United States)
Additional Journal Information:
Journal Volume: 79:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EPIDERMIS; BIOLOGICAL RADIATION EFFECTS; PSORALEN; RADIOSENSITIVITY EFFECTS; BIOLOGICAL PATHWAYS; DOSE-RESPONSE RELATIONSHIPS; MICE; RADIATION DOSES; ULTRAVIOLET RADIATION; ANIMAL TISSUES; ANIMALS; ANTICOAGULANTS; BIOLOGICAL EFFECTS; BODY; COUMARINS; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; EPITHELIUM; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SKIN; TISSUES; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)

Citation Formats

Young, A R, and Magnus, I A. The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens. United States: N. p., 1982. Web. doi:10.1111/1523-1747.ep12500064.
Young, A R, & Magnus, I A. The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens. United States. https://doi.org/10.1111/1523-1747.ep12500064
Young, A R, and Magnus, I A. 1982. "The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens". United States. https://doi.org/10.1111/1523-1747.ep12500064.
@article{osti_6561869,
title = {The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens},
author = {Young, A R and Magnus, I A},
abstractNote = {The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied. It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen. The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation. A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent. This suggests that DNA crosslink lesions may play a rle in sunburn cell production.},
doi = {10.1111/1523-1747.ep12500064},
url = {https://www.osti.gov/biblio/6561869}, journal = {J. Invest. Dermatol.; (United States)},
number = ,
volume = 79:4,
place = {United States},
year = {Fri Oct 01 00:00:00 EDT 1982},
month = {Fri Oct 01 00:00:00 EDT 1982}
}