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Title: Relationship of five anthropometric measurements at age 18 to radiation dose among atomic bomb survivors exposed in utero

Five body measurements-standing height, body weight, sitting height, chest circumference and intercristal diameter-of 18-year-old atomic bomb survivors exposed in utero in Hiroshima and Nagasaki were analyzed in relation to DS86 uterine dose. Age in utero was divided into four periods: 0-7, 8-15, 16-25 and [>=]26 weeks. This categorization is based upon the study of radiation-induced brain damage. The linear regression analyses for these five variables showed significant decreases with increasing dose. The regression coefficients were -2.65 cm/Gy for standing height, -2.46 kg/Gy for body weight, -0.92 cm/Gy for sitting height, -1.37 cm/Gy for chest circumference and -0.32 cm/Gy for intercristal diameter. The multivariate test statistic for the overall dose effect on five body measurements was significant, but the interaction between dose and gestational period was not significant. Principal-component analysis was applied to the five variables. For the first-component scores, the dose effect was significant, but the interaction between dose and gestational period was not significant. For the second-component scores, the dose effect was significant specifically at 0.7 weeks. The radiation dose effect on the second principal component found at 0-7 weeks of gestation suggests that malformation occur in this period. 17 refs., 2 figs., 4 tabs.
Authors:
 [1]
  1. (Radiation Effects Research Foundation, Minami-ku (Japan))
Publication Date:
OSTI Identifier:
6551260
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiation Research; (United States); Journal Volume: 138:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; A-BOMB SURVIVORS; PRENATAL IRRADIATION; ADULTS; DOSE-RESPONSE RELATIONSHIPS; HEIGHT; WEIGHT; BIOLOGICAL RADIATION EFFECTS; EPIDEMIOLOGY; HIROSHIMA; NAGASAKI; RADIATION DOSES; AGE GROUPS; ASIA; BIOLOGICAL EFFECTS; DEVELOPED COUNTRIES; DIMENSIONS; DOSES; HUMAN POPULATIONS; IRRADIATION; JAPAN; POPULATIONS; PRENATAL EXPOSURE; RADIATION EFFECTS 560151* -- Radiation Effects on Animals-- Man; 551000 -- Physiological Systems