Measurement of fecal /sup 14/C excretion

Journal Article · Mon Nov 01 00:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:6531715

Kumaran, K A; Wiener, N S; Katz, J B

Simultaneous measurements of fecal /sup 14/C and expired /sup 14/CO/sub 2/ in the breath are necessary to evaluate patients with various ileal abnormalities and bile salt malabsorption. Following the oral ingestion of the labeled bile acid, glycine-(I-/sup 14/C)cholic acid, detection of increased fecal /sup 14/C without abnormal expiration of /sup 14/CO/sub 2/ identifies patients with ileal resection. This contrasts with the normal fecal /sup 14/C content and abnormal expired /sup 14/CO/sub 2/ found in patients with bacterial overgrowth. Fecal /sup 14/C content was determined by utilizing Van Slyke combustion of the specimen and trapping the liberated /sup 14/CO/sub 2/ with Scintisorb C. The method is simple, rapid, and accurate, and expands the diagnostic usefulness of the bile salt absorption test.

• Research Organization: The Mt. Sinai Medical Center, Cleveland, Ohio
• OSTI ID: 6531715
• Journal Information: J. Nucl. Med.; (United States), Vol. 23:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CARBON 14 COMPOUNDS
DIAGNOSTIC USES
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
CARBON DIOXIDE
CHOLIC ACID
FECES
INTESTINAL ABSORPTION
PATIENTS
SMALL INTESTINE
ABSORPTION
BILE ACIDS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CARBOXYLIC ACIDS
CHALCOGENIDES
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INTESTINES
LABELLED COMPOUNDS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
STEROIDS
STEROLS
UPTAKE
USES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550201 - Biochemistry- Tracer Techniques