An essential yeast gene encoding a TTAGGG repeat-binding protein

Journal Article · Mon Feb 01 00:00:00 EST 1993 · Molecular and Cellular Biology; (United States)

DOI:https://doi.org/10.1128/MCB.13.2.1306· OSTI ID:6528868

Brigati, C ^[1]; Kurtz, S; Balderes, D; Shore, D ^[2]; Vidali, G ^[3]

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1. Columbia Univ., New York, NY (United States) Istituto Nazionale per la Ricerca sul Cancro, Genoa (Italy)
2. Columbia Univ., New York, NY (United States)
3. Istituto Nazionale per la Ricerca sul Cancro, Genoa (Italy)

Among all eukaryotes examined to date, telomere is a highly conserved structure. It is designed to protect chromosomes from degradation and fusion. Telomeres are composed of multiple repeats of short sequence elements and range in length from a few repeat units to > kb. The repeated sequence TTAGGG is found at telomeres in all vertebrates, certain slime molds, and trypanosomes. Because sequence TTAGGG is present at the telomere of all of these divergent organisms, it is likely that it constitutes a binding site for highly conserved proteins with important roles in chromosomal structure and function. The occurrence of a TTAGGG-binding activity in Saccharomyces cerevisiae and the presence of TTAGGG sequences at telomere junctions raise the possibility that there is a related factor with a functional role at telomeres in S. cervisiae. The research in this paper tests this hypothesis. 33 refs., 6 figs., 1 tab.

• OSTI ID: 6528868
• Journal Information: Molecular and Cellular Biology; (United States), Vol. 13:2; ISSN 0270-7306
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
YEASTS
AMINO ACID SEQUENCE
CHROMOSOMAL ABERRATIONS
DNA SEQUENCING
GENETIC MAPPING
PROTEIN STRUCTURE
PROTEINS
TRANSCRIPTION FACTORS
EUMYCOTA
FUNGI
MAPPING
MICROORGANISMS
MOLECULAR STRUCTURE
MUTATIONS
ORGANIC COMPOUNDS
PLANTS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics
550200 - Biochemistry