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Title: Effects of epidermal growth factor on neural crest cells in tissue culture

Abstract

Epidermal growth factor (EGF) stimulates the release of hyaluronic acid (HA) and chondroitin sulfate proteoglycan (CSPG) from quail trunk neural crest cultures in a dose-dependent fashion. It also promotes the expression of cell-associated heparan sulfate proteoglycan (HSPG) as detected by immunofluorescence and immunoprecipitation of the /sup 3/H-labeled proteoglycan. Furthermore, EGF stimulates (/sup 3/H)thymidine incorporation into total cell DNA. These results raise the possibility that EGF or an analogous growth factor is involved in regulation of neural crest cell morphogenesis.

Authors:
;
Publication Date:
Research Org.:
Univ. of California, Davis
OSTI Identifier:
6524195
Resource Type:
Journal Article
Journal Name:
Exp. Cell Res.; (United States)
Additional Journal Information:
Journal Volume: 169:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GLUCOPROTEINS; BIOSYNTHESIS; POLYPEPTIDES; BIOCHEMISTRY; TRITIUM COMPOUNDS; ANIMAL CELLS; CELL CULTURES; CHONDROITIN; DNA; EPIDERMIS; FLUORESCENCE; GROWTH; HYALURONIC ACID; IODINE 125; SULFATES; THYMIDINE; AMINES; ANIMAL TISSUES; AZINES; BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CHEMISTRY; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EPITHELIUM; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LUMINESCENCE; MUCOPOLYSACCHARIDES; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PEPTIDES; POLYSACCHARIDES; PROTEINS; PYRIMIDINES; RADIOISOTOPES; RIBOSIDES; SACCHARIDES; SKIN; SULFUR COMPOUNDS; SYNTHESIS; TISSUES; 550301* - Cytology- Tracer Techniques

Citation Formats

Erickson, C A, and Turley, E A. Effects of epidermal growth factor on neural crest cells in tissue culture. United States: N. p., 1987. Web. doi:10.1016/0014-4827(87)90189-3.
Erickson, C A, & Turley, E A. Effects of epidermal growth factor on neural crest cells in tissue culture. United States. https://doi.org/10.1016/0014-4827(87)90189-3
Erickson, C A, and Turley, E A. 1987. "Effects of epidermal growth factor on neural crest cells in tissue culture". United States. https://doi.org/10.1016/0014-4827(87)90189-3.
@article{osti_6524195,
title = {Effects of epidermal growth factor on neural crest cells in tissue culture},
author = {Erickson, C A and Turley, E A},
abstractNote = {Epidermal growth factor (EGF) stimulates the release of hyaluronic acid (HA) and chondroitin sulfate proteoglycan (CSPG) from quail trunk neural crest cultures in a dose-dependent fashion. It also promotes the expression of cell-associated heparan sulfate proteoglycan (HSPG) as detected by immunofluorescence and immunoprecipitation of the /sup 3/H-labeled proteoglycan. Furthermore, EGF stimulates (/sup 3/H)thymidine incorporation into total cell DNA. These results raise the possibility that EGF or an analogous growth factor is involved in regulation of neural crest cell morphogenesis.},
doi = {10.1016/0014-4827(87)90189-3},
url = {https://www.osti.gov/biblio/6524195}, journal = {Exp. Cell Res.; (United States)},
number = ,
volume = 169:2,
place = {United States},
year = {Wed Apr 01 00:00:00 EST 1987},
month = {Wed Apr 01 00:00:00 EST 1987}
}