Use of submitochondrial particles for prediction of chemical toxicity in man
- Univ. of Wisconsin, Madison (USA)
Three bioassays which use submitochondrial electron transport particles (ETP) to evaluate chemical toxicity have been developed. These tests were initially designed for use in water quality monitoring. However, they are also valuable for assessing the toxicity of new and existing chemicals. The current investigation studies the ability of these procedures to predict in vivo tissue concentrations associated with clinical illness in man. To examine this potential, data obtained using the mitochondrial tests were compared to chemical concentrations measured in human blood samples obtained during the acute stage of chemical-induced illness. Twenty-nine chemicals were used in the comparison including 6 metals, 8 pesticides, 5 drugs, 4 solvents and 3 alcohols. The results of this study support the hypothesis that the mitochondrial bioassays can successfully predict the in vivo toxicity of many diverse chemicals. Properly performed and evaluated, these short-term tests may be useful in identifying potential environmental pollutants, selecting compounds for market development and prioritizing substances for more extensive testing in animals.
- OSTI ID:
- 6519232
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 44:5; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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MITOCHONDRIA
ELECTRON TRANSFER
POLLUTANTS
BIOASSAY
ALCOHOLS
BLOOD
MAN
METALS
NADH2
NITRO COMPOUNDS
PESTICIDES
QUINOLINES
SOLVENTS
TOXICITY
ANIMALS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL MATERIALS
BODY FLUIDS
CELL CONSTITUENTS
COENZYMES
ELEMENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
MATERIALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
PRIMATES
PYRIDINES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology