Effect of ribose on thallium-201 myocardial redistribution
Abstract
Myocardial S Tl redistribution after transient ischemia may be too slow to allow identification of a reversible myocardial defect within the routine S Tl imaging period. To determine whether S Tl redistribution could be affected by a metabolic intervention, intravenous ribose was administered postischemia. Seventeen domestic swine were subjected to a 10-min ischemic period followed by either a 30-min i.v. ribose (n = 8) or saline (n = 9) infusion. Thallium-201 was injected during ischemia and myocardial S Tl activity was continuously monitored in ischemic and nonischemic regions with miniature CdTe radiation detection probes. Coronary flow in the ischemic region was reduced to 25% of that in the nonischemic regions in both saline and ribose groups. The S Tl time-activity curves demonstrated a significant enhancement of % S Tl redistribution in the ribose-treated animals at the end of ribose infusion: Ribose (48 +/- 11%), Saline (20 +/- 4%), p less than 0.05. Alteration of S Tl kinetics by ribose may permit earlier recognition of S Tl myocardial redistribution after transient ischemia.
- Authors:
- Publication Date:
- Research Org.:
- Oregon Health Sciences Univ., Portland (USA)
- OSTI Identifier:
- 6516809
- Resource Type:
- Journal Article
- Journal Name:
- J. Nucl. Med.; (United States)
- Additional Journal Information:
- Journal Volume: 29:12
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; BLOOD FLOW; ISCHEMIA; DIAGNOSIS; THALLIUM 201; UPTAKE; MYOCARDIUM; RIBOSE; SWINE; ALDEHYDES; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; DOMESTIC ANIMALS; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MONOSACCHARIDES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PENTOSES; RADIOISOTOPES; SACCHARIDES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; VASCULAR DISEASES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Angello, D A, Wilson, R A, and Gee, D. Effect of ribose on thallium-201 myocardial redistribution. United States: N. p., 1988.
Web.
Angello, D A, Wilson, R A, & Gee, D. Effect of ribose on thallium-201 myocardial redistribution. United States.
Angello, D A, Wilson, R A, and Gee, D. 1988.
"Effect of ribose on thallium-201 myocardial redistribution". United States.
@article{osti_6516809,
title = {Effect of ribose on thallium-201 myocardial redistribution},
author = {Angello, D A and Wilson, R A and Gee, D},
abstractNote = {Myocardial S Tl redistribution after transient ischemia may be too slow to allow identification of a reversible myocardial defect within the routine S Tl imaging period. To determine whether S Tl redistribution could be affected by a metabolic intervention, intravenous ribose was administered postischemia. Seventeen domestic swine were subjected to a 10-min ischemic period followed by either a 30-min i.v. ribose (n = 8) or saline (n = 9) infusion. Thallium-201 was injected during ischemia and myocardial S Tl activity was continuously monitored in ischemic and nonischemic regions with miniature CdTe radiation detection probes. Coronary flow in the ischemic region was reduced to 25% of that in the nonischemic regions in both saline and ribose groups. The S Tl time-activity curves demonstrated a significant enhancement of % S Tl redistribution in the ribose-treated animals at the end of ribose infusion: Ribose (48 +/- 11%), Saline (20 +/- 4%), p less than 0.05. Alteration of S Tl kinetics by ribose may permit earlier recognition of S Tl myocardial redistribution after transient ischemia.},
doi = {},
url = {https://www.osti.gov/biblio/6516809},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 29:12,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 1988},
month = {Thu Dec 01 00:00:00 EST 1988}
}