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Title: Effect of ribose on thallium-201 myocardial redistribution

Abstract

Myocardial S Tl redistribution after transient ischemia may be too slow to allow identification of a reversible myocardial defect within the routine S Tl imaging period. To determine whether S Tl redistribution could be affected by a metabolic intervention, intravenous ribose was administered postischemia. Seventeen domestic swine were subjected to a 10-min ischemic period followed by either a 30-min i.v. ribose (n = 8) or saline (n = 9) infusion. Thallium-201 was injected during ischemia and myocardial S Tl activity was continuously monitored in ischemic and nonischemic regions with miniature CdTe radiation detection probes. Coronary flow in the ischemic region was reduced to 25% of that in the nonischemic regions in both saline and ribose groups. The S Tl time-activity curves demonstrated a significant enhancement of % S Tl redistribution in the ribose-treated animals at the end of ribose infusion: Ribose (48 +/- 11%), Saline (20 +/- 4%), p less than 0.05. Alteration of S Tl kinetics by ribose may permit earlier recognition of S Tl myocardial redistribution after transient ischemia.

Authors:
; ;
Publication Date:
Research Org.:
Oregon Health Sciences Univ., Portland (USA)
OSTI Identifier:
6516809
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 29:12
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; BLOOD FLOW; ISCHEMIA; DIAGNOSIS; THALLIUM 201; UPTAKE; MYOCARDIUM; RIBOSE; SWINE; ALDEHYDES; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; DOMESTIC ANIMALS; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MONOSACCHARIDES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PENTOSES; RADIOISOTOPES; SACCHARIDES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; VASCULAR DISEASES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Angello, D A, Wilson, R A, and Gee, D. Effect of ribose on thallium-201 myocardial redistribution. United States: N. p., 1988. Web.
Angello, D A, Wilson, R A, & Gee, D. Effect of ribose on thallium-201 myocardial redistribution. United States.
Angello, D A, Wilson, R A, and Gee, D. 1988. "Effect of ribose on thallium-201 myocardial redistribution". United States.
@article{osti_6516809,
title = {Effect of ribose on thallium-201 myocardial redistribution},
author = {Angello, D A and Wilson, R A and Gee, D},
abstractNote = {Myocardial S Tl redistribution after transient ischemia may be too slow to allow identification of a reversible myocardial defect within the routine S Tl imaging period. To determine whether S Tl redistribution could be affected by a metabolic intervention, intravenous ribose was administered postischemia. Seventeen domestic swine were subjected to a 10-min ischemic period followed by either a 30-min i.v. ribose (n = 8) or saline (n = 9) infusion. Thallium-201 was injected during ischemia and myocardial S Tl activity was continuously monitored in ischemic and nonischemic regions with miniature CdTe radiation detection probes. Coronary flow in the ischemic region was reduced to 25% of that in the nonischemic regions in both saline and ribose groups. The S Tl time-activity curves demonstrated a significant enhancement of % S Tl redistribution in the ribose-treated animals at the end of ribose infusion: Ribose (48 +/- 11%), Saline (20 +/- 4%), p less than 0.05. Alteration of S Tl kinetics by ribose may permit earlier recognition of S Tl myocardial redistribution after transient ischemia.},
doi = {},
url = {https://www.osti.gov/biblio/6516809}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 29:12,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 1988},
month = {Thu Dec 01 00:00:00 EST 1988}
}