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Title: Inactivation of human T-lymphotropic virus type III/lymphadenopathy-associated virus by formaldehyde-based reagents

Abstract

Neutral buffered Formalin, a fixative used in most pathology laboratories, was found to inactivate human T-lymphotropic virus type III/lymphadenopathy-associated virus. Preparations containing this virus with infectivity titers of > 10/sup 5/ were treated with 1% or greater neutral buffered Formalin; after treatment, virus was undetectable (titer, <10/sup 1/). In addition, when infected phytohemagglutinin-stimulated lymphocytes were treated with paraformaldehyde, transmission of the virus to other such lymphocytes was eliminated. 4 references, 2 tables.

Authors:
; ;
Publication Date:
Research Org.:
Centers for Disease Control, Atlanta, GA
OSTI Identifier:
6516420
Resource Type:
Journal Article
Journal Name:
Appl. Environ. Microbiol.; (United States)
Additional Journal Information:
Journal Volume: 53:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FORMALDEHYDE; TOXICITY; VIRUSES; INFECTIVITY; EXPERIMENTAL DATA; INACTIVATION; LYMPHOCYTES; MAN; ALDEHYDES; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DATA; INFORMATION; LEUKOCYTES; MAMMALS; MATERIALS; MICROORGANISMS; NUMERICAL DATA; ORGANIC COMPOUNDS; PARASITES; PRIMATES; SOMATIC CELLS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Martin, L S, Loskoski, S L, and McDougal, J S. Inactivation of human T-lymphotropic virus type III/lymphadenopathy-associated virus by formaldehyde-based reagents. United States: N. p., 1987. Web.
Martin, L S, Loskoski, S L, & McDougal, J S. Inactivation of human T-lymphotropic virus type III/lymphadenopathy-associated virus by formaldehyde-based reagents. United States.
Martin, L S, Loskoski, S L, and McDougal, J S. 1987. "Inactivation of human T-lymphotropic virus type III/lymphadenopathy-associated virus by formaldehyde-based reagents". United States.
@article{osti_6516420,
title = {Inactivation of human T-lymphotropic virus type III/lymphadenopathy-associated virus by formaldehyde-based reagents},
author = {Martin, L S and Loskoski, S L and McDougal, J S},
abstractNote = {Neutral buffered Formalin, a fixative used in most pathology laboratories, was found to inactivate human T-lymphotropic virus type III/lymphadenopathy-associated virus. Preparations containing this virus with infectivity titers of > 10/sup 5/ were treated with 1% or greater neutral buffered Formalin; after treatment, virus was undetectable (titer, <10/sup 1/). In addition, when infected phytohemagglutinin-stimulated lymphocytes were treated with paraformaldehyde, transmission of the virus to other such lymphocytes was eliminated. 4 references, 2 tables.},
doi = {},
url = {https://www.osti.gov/biblio/6516420}, journal = {Appl. Environ. Microbiol.; (United States)},
number = ,
volume = 53:4,
place = {United States},
year = {Wed Apr 01 00:00:00 EST 1987},
month = {Wed Apr 01 00:00:00 EST 1987}
}