Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography
A 48-year-old man with typical Huntington's disease was investigated with computed tomography (CT) and positron emission tomography. Regional cerebral blood flow, oxygen extraction, oxygen and glucose utilization, L-Dopa uptake, and dopamine (D2) receptor binding were measured using several positron-labelled tracers. CT showed slight atrophy of the head of caudate but no cortical atrophy, although distinct frontal lobe dysfunction was present on psychometric testing. Oxygen and glucose metabolism and cerebral blood flow were decreased in the striata and to a lesser extent in frontal cortex. Cerebral blood flow was in the low normal range throughout the remainder of the brain. A normal metabolic ratio was found in all regions, since the changes in glucose utilization paralleled those in oxygen consumption. The capacity of the striatum to store dopamine as assessed by L-( YF)-fluorodopa uptake was normal, but dopamine (D2) receptor binding was decreased when compared to normal subjects.
- Research Organization:
- Hammersmith Hospital, London (England)
- OSTI ID:
- 6516336
- Journal Information:
- Mov. Disord.; (United States), Vol. 1:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CEREBRAL CORTEX
POSITRON COMPUTED TOMOGRAPHY
DOPAMINE
RECEPTORS
GLUCOSE
METABOLISM
NERVOUS SYSTEM DISEASES
DIAGNOSIS
ATROPHY
BIOCHEMICAL REACTION KINETICS
BLOOD FLOW
DOPA
FLUORINE 18
OXYGEN
SPIPERONE
ALDEHYDES
AMINES
AMINO ACIDS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
HYDROXY COMPOUNDS
ISOTOPES
KINETICS
LIGHT NUCLEI
MEMBRANE PROTEINS
MONOSACCHARIDES
NERVOUS SYSTEM
NEUROREGULATORS
NONMETALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHENOLS
POLYPHENOLS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
SACCHARIDES
SYMPATHOMIMETICS
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques