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Title: Effect of tyrosine administration on duodenal ulcer induced by cysteamine in the rat

Duodenal ulcers were produced by administering cysteamine to rats. Pretreatment with the catecholamine precursor, L-tyrosine (40 mg/100 g i.p. for 5 days), decreased the intensity of duodenal ulcers induced by cysteamine. Equimolar doses of tyrosine methyl ester (51.2 mg/100 g i.p. or s.c.) were equally effective in reducing ulcer intensity. Other amino acids (i.e., alanine, aspartic acid, glutamic acid, glycine, leucine, lysine, tryptophan and valine) did not prevent experimental duodenal ulcers. Coadministration of other large neutral amino acids (e.g., leucine and valine) that compete with tyrosine for uptake into the brain did not inhibit the effect of tyrosine on duodenal ulcers induced by cysteamine. Gastric, duodenal and brain dopamine concentrations were increased 1 hr after the injection of tyrosine methyl ester (25.6 mg/100 g s.c.). These results suggest that the effect of tyrosine on duodenal ulcer induced by cysteamine may be mediated by changes in gastrointestinal dopamine metabolism.
Authors:
;
Publication Date:
OSTI Identifier:
6515688
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Pharmacol. Exp. Ther.; (United States); Journal Volume: 3
Research Org:
Brigham and Women's Hospital, Boston, MA
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MEA; TOXICITY; TYROSINE; BIOLOGICAL EFFECTS; ULCERS; PATHOGENESIS; AMINO ACIDS; DOPAMINE; METABOLISM; RADIOPROTECTIVE SUBSTANCES; RATS; SMALL INTESTINE; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CARBOXYLIC ACIDS; CARDIOTONICS; CARDIOVASCULAR AGENTS; DIGESTIVE SYSTEM; DRUGS; GASTROINTESTINAL TRACT; HYDROXY ACIDS; HYDROXY COMPOUNDS; INTESTINES; MAMMALS; NEUROREGULATORS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PHENOLS; POLYPHENOLS; RODENTS; SYMPATHOMIMETICS; THIOLS; VERTEBRATES 560152* -- Radiation Effects on Animals-- Animals