Thyroid tumors following /sup 131/I or localized x irradiation to the thyroid and pituitary glands in rats
Three thousand 6-week-old female Long-Evans rats were randomly assigned to 10 equal treatment groups. Three groups were injected intraperitoneally with 0.48, 1.9, and 5.4 ..mu..Ci of Na /sup 131/I yielding mean thyroid doses of 30, 330, and 850 rad, respectively. Three groups were irradiated with 94, 410, and 1060 rad from localized X ray to the thyroid. One group was irradiated with 410 rad to the pituitary, and another group was given 410 rad to both the thyroid and the pituitary with localized X rays. The remaining two groups of animals were used as separate sham-irradiated controls for the two types of radiation. All the surviving animals were killed 2 years later. Results derived from this study indicate that: (a) The proportion of animals with thyroid carcinoma is similar for /sup 131/I and X irradiation within the dose range of 0-1000 rad. (b) The thryoid carcinoma dose-response functions fitted by the least-squares method are nearly proportional to the square root of the thyroid dose. (c) Thyroid carcinoma induction appears to be independent of the dose rates resulting from the radiations used in this study. (d) A localized X-ray dose of 410 rad to the pituitary, whether the dose was administered concomitantly with thyroid irradiation or without thyroid irradiation, did not modify the risk of thyroid tumor.
- Research Organization:
- Food and Drug Administration, Rockville, MD
- OSTI ID:
- 6514383
- Journal Information:
- Radiat. Res.; (United States), Vol. 92:2
- Country of Publication:
- United States
- Language:
- English
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ADENOMAS
RADIOINDUCTION
CARCINOMAS
THYROID
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
IODINE 131
PITUITARY GLAND
RATS
RISK ASSESSMENT
X RADIATION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IONIZING RADIATIONS
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
VERTEBRATES
560162* - Radionuclide Effects
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Microorganisms
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560152 - Radiation Effects on Animals- Animals