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Title: Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950-76: relationship to radiation dose absorbed by marrow

The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From October 1950 to December 1976, 29 cases of multiple myeloma were confirmed in this sample. Our analysis shows that the standardized relative risk (RR) adjusted for city, sex, and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 years. The estimaged risk in these individuals is approximately 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 years or more after exposure.
Authors:
 [1] ; ; ;
  1. (Nagasaki Univ. School of Medicine, Japan)
Publication Date:
OSTI Identifier:
6514310
Resource Type:
Journal Article
Resource Relation:
Journal Name: JNCI, J. Natl. Cancer Inst.; (United States); Journal Volume: 69:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; DELAYED RADIATION EFFECTS; BONE MARROW CELLS; NEOPLASMS; RADIATION DOSES; HIROSHIMA; NAGASAKI; NUCLEAR EXPLOSIONS; NUCLEAR WEAPONS; ANIMAL CELLS; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; EXPLOSIONS; HUMAN POPULATIONS; JAPAN; POPULATIONS; RADIATION EFFECTS; SOMATIC CELLS; WEAPONS 560151* -- Radiation Effects on Animals-- Man