skip to main content

Title: Modeling the effect of intermittent monochloramine concentrations on survival of freshwater fish

In this project we developed and evaluated mathematical models to predict toxicity to freshwater fish during continuous and intermittent exposures to monochloramine (NH[sub 2]Cl). A simple concentration x time model and three models based on the general Mancini uptake-depuration model were included in this analysis. Performance of the models was evaluated using published continuous- and intermittent-exposure toxicity data for rainbow trout (Oncorhynchus mykiss) and common shiners (Notropis cornutus) exposed to NH[sub 2]Cl at 12[degrees]C and 25[degrees]C, respectively. Currently used models predicted LC50s for the first four pulses during intermittent exposures moderately well when the fish were exposed to repeated 2-h pulse/22-h recovery cycles; however, predicted pulse LC50s appeared to diverge from the trend for the observed LC50s as the number of pulses increased. This accuracy may be suitable for regulatory purposes, if LC50s are to be predicted for only the initial few cycles of a pulse-recovery exposure regime. However, itappears that details of the complex physiological mechanisms of monochloramine toxicity may not be adequately modeled by the Mancini type models or by the simplistic concentration x time model. If more accuratepredictions are desired, either more complex models or other models based on different basic structures must be developed. Development ofmore » these new models should be based on studies of the physiological processes underlying uptake and depuration of chlorine-related compounds.« less
Authors:
; ;  [1]
  1. (Wyoming Univ., Laramie, WY (United States))
Publication Date:
OSTI Identifier:
6501118
Report Number(s):
EPRI-TR-102057
Resource Type:
Technical Report
Research Org:
Electric Power Research Inst., Palo Alto, CA (United States); Wyoming Univ., Laramie, WY (United States). Fish Physiology and Toxicology Lab.
Sponsoring Org:
EPRI; Electric Power Research Inst., Palo Alto, CA (United States)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AMINES; TOXICITY; MATHEMATICAL MODELS; ACUTE EXPOSURE; BIOLOGICAL REPAIR; CHLORINE COMPOUNDS; FISHES; LETHAL DOSES; MORTALITY; TIME DEPENDENCE; TROUT; ANIMALS; AQUATIC ORGANISMS; BIOLOGICAL RECOVERY; DOSES; HALOGEN COMPOUNDS; ORGANIC COMPOUNDS; REPAIR; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology