Absorption and disposition of /sup 203/Hg in the pregnant and nonpregnant hamster following oral administration of (/sup 203/Hg)methylmercuric chloride

Journal Article · Sun Feb 01 00:00:00 EST 1981 · Environ. Res.; (United States)

OSTI ID:6500950

Reuhl, K R ^[1]; Pounds, J G

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1. National Center for Toxicological Research, Jefferson AR

The absorption and disposition of /sup 203/Hg was determined in pregnant and nonpregnant golden hamsters by means of ..gamma.. scintillation spectroscopy. The animals were given 5 ..mu..Ci(/sup 203/Hg)methylmercuric chloride orally on gestation Day 9. Urine and feces were collected until Day 15, when the animals were sacrificed. Adult and fetal tissues were analyzed for /sup 203/Hg concentrations. At 12 h postintubation, pregnant hamsters absorbed more of the administered dose and eliminated less methylmercury in the feces than nonpregnant animals. Beyond 12 h postintubation, the absorption and elimination patterns were similar in both groups. Comparison of organs from pregnant and nonpregnant animals revealed greater methylmercury concentrations in the cerebella, pons-medullas, and spleens of pregnant females. The fetal head was found to contain significantly more methylmercury than the fetal body.

• OSTI ID: 6500950
• Journal Information: Environ. Res.; (United States), Vol. 24:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MERCURY 203
RADIONUCLIDE KINETICS
CEREBELLUM
FECES
FETUSES
HAMSTERS
LABELLED COMPOUNDS
MERCURY CHLORIDES
ORAL ADMINISTRATION
ORGANS
PREGNANCY
QUANTITY RATIO
SCINTISCANNING
SPLEEN
TISSUE DISTRIBUTION
UPTAKE
URINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
ISOTOPES
MAMMALS
MATERIALS
MERCURY COMPOUNDS
MERCURY HALIDES
MERCURY ISOTOPES
NERVOUS SYSTEM
NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
VERTEBRATES
WASTES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)