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Title: Indium-111-labeled platelet scintigraphy in carotid atherosclerosis

Abstract

We evaluated platelet accumulation in carotid arteries by means of a dual-radiotracer method, using indium-111-labeled platelets and technetium-99m-labeled human serum albumin, in 123 patients (92 men, 31 women; median age 60 years). Sixty patients had symptoms of transient ischemic carotid artery disease, and 63 patients with peripheral arterial occlusive disease served as controls. Antiplatelet treatment with acetylsalicylic acid was taken by 53 of the 123 patients. In 36 of the 60 symptomatic patients, platelet scintigraphy was repeated 3-4 days after carotid endarterectomy. Comparison of different scintigraphic parameters (platelet accumulation index and percent of the injected dose of labeled platelets at the carotid bifurcation) showed no significant differences between symptomatic and asymptomatic patients, and the severity of stenosis and the presence of plaque ulceration also had no influence on the parameters. There was no difference between patients with a short (less than 4 weeks) or long (greater than 4 weeks) interval from the last transient ischemic attack to scintigraphy and no difference between patients with or without antiplatelet treatment. Classifying the patients according to plaque morphology judged by high-resolution real-time ultrasonography also demonstrated no differences. No significant correlation was found between any scintigraphic parameter and other platelet function parameters such asmore » platelet survival time, platelet turnover rate, and concentration of platelet-specific proteins. Quantification of platelet deposition after carotid endarterectomy in 36 patients demonstrated a significant increase of the median platelet accumulation index and the percent injected dose index.« less

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
I. Medical Univ. Clinic, Vienna (Austria)
OSTI Identifier:
6499516
Resource Type:
Journal Article
Journal Name:
Stroke; (United States)
Additional Journal Information:
Journal Volume: 20:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIOSCLEROSIS; DIAGNOSIS; CAROTID ARTERIES; SCINTISCANNING; ALBUMINS; BLOOD PLATELETS; INDIUM 111; ISOMERIC NUCLEI; PATIENTS; TECHNETIUM 99; ULTRASONOGRAPHY; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD VESSELS; BODY; BODY FLUIDS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; VASCULAR DISEASES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550600 - Medicine

Citation Formats

Minar, E, Ehringer, H, Dudczak, R, Schoefl, R J, Jung, M, Koppensteiner, R, Ahmadi, R, and Kretschmer, G. Indium-111-labeled platelet scintigraphy in carotid atherosclerosis. United States: N. p., 1989. Web. doi:10.1161/01.STR.20.1.27.
Minar, E, Ehringer, H, Dudczak, R, Schoefl, R J, Jung, M, Koppensteiner, R, Ahmadi, R, & Kretschmer, G. Indium-111-labeled platelet scintigraphy in carotid atherosclerosis. United States. https://doi.org/10.1161/01.STR.20.1.27
Minar, E, Ehringer, H, Dudczak, R, Schoefl, R J, Jung, M, Koppensteiner, R, Ahmadi, R, and Kretschmer, G. 1989. "Indium-111-labeled platelet scintigraphy in carotid atherosclerosis". United States. https://doi.org/10.1161/01.STR.20.1.27.
@article{osti_6499516,
title = {Indium-111-labeled platelet scintigraphy in carotid atherosclerosis},
author = {Minar, E and Ehringer, H and Dudczak, R and Schoefl, R J and Jung, M and Koppensteiner, R and Ahmadi, R and Kretschmer, G},
abstractNote = {We evaluated platelet accumulation in carotid arteries by means of a dual-radiotracer method, using indium-111-labeled platelets and technetium-99m-labeled human serum albumin, in 123 patients (92 men, 31 women; median age 60 years). Sixty patients had symptoms of transient ischemic carotid artery disease, and 63 patients with peripheral arterial occlusive disease served as controls. Antiplatelet treatment with acetylsalicylic acid was taken by 53 of the 123 patients. In 36 of the 60 symptomatic patients, platelet scintigraphy was repeated 3-4 days after carotid endarterectomy. Comparison of different scintigraphic parameters (platelet accumulation index and percent of the injected dose of labeled platelets at the carotid bifurcation) showed no significant differences between symptomatic and asymptomatic patients, and the severity of stenosis and the presence of plaque ulceration also had no influence on the parameters. There was no difference between patients with a short (less than 4 weeks) or long (greater than 4 weeks) interval from the last transient ischemic attack to scintigraphy and no difference between patients with or without antiplatelet treatment. Classifying the patients according to plaque morphology judged by high-resolution real-time ultrasonography also demonstrated no differences. No significant correlation was found between any scintigraphic parameter and other platelet function parameters such as platelet survival time, platelet turnover rate, and concentration of platelet-specific proteins. Quantification of platelet deposition after carotid endarterectomy in 36 patients demonstrated a significant increase of the median platelet accumulation index and the percent injected dose index.},
doi = {10.1161/01.STR.20.1.27},
url = {https://www.osti.gov/biblio/6499516}, journal = {Stroke; (United States)},
number = ,
volume = 20:1,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}