High resolution /sup 10/B and /sup 11/B nuclear magnetic resonance (NMR) spectroscopy of Na/sub 2/B/sub 12/H/sub 11/SH impurities and metabolites

Conference · Fri Jan 01 00:00:00 EST 1988

OSTI ID:6498118

Samsel, E G; Miller, D L

High-resolution /l brace//sup 1/H/r brace//sup 10/B and /sup 11/B nuclear magnetic resonance (NMR) has been investigated as a tool for in-vitro examination and analysis of the proposed neutron capture drug, Na/sub 2/B/sub 12/H/sub 11/SH, its impurities, and its metabolites. The instrument used was a 7 T, superconducting IBM NR-300, operating at 96.3 MHz for /sup 11/B and 32.2 MHz for /sup 10/B. High-quality spectra of both nuclei were obtained at concentrations in the 100-500 ppM (boron) range with acquisition periods of minutes to a few hours. A broad background resonance due to borosilicate glass probe components limits the sensitivity of this instrument. Nevertheless, signals for both nuclei were visible in dog blood serum samples at boron concentrations as low as 30 ppM. 2 refs., 1 tab.

• Research Organization: EG and G Idaho, Inc., Idaho Falls (USA)
• DOE Contract Number: AC07-76ID01570
• OSTI ID: 6498118
• Report Number(s): EGG-M-88042; CONF-8805150-8; ON: DE89005174
• Resource Relation: Conference: 4. international conference on neutron capture therapy, Bremen, F.R. Germany, 31 May 1988; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEUTRON CAPTURE THERAPY
TESTING
NUCLEAR MAGNETIC RESONANCE
EVALUATION
BLOOD SERUM
BORON 10
BORON 11
DOGS
IN VITRO
METABOLITES
ANIMALS
BORON ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MEDICINE
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIOLOGY
RADIOTHERAPY
RESONANCE
STABLE ISOTOPES
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)