Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene

Journal Article · Tue Feb 01 00:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1088· OSTI ID:6483436

Engle, L J; Kennett, R H ^[1]

---

1. Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)

The mouse dilute gene encodes a novel type of non-muscle myosin that structurally combines elements from both nonmuscle myosin type I and nonmuscle myosin type II. Phenotypically, mutations in the mouse dilute gene result not only in the lightening of coat color, but also in the onset of severe neurological defects shortly after birth. This may indicate that the mouse dilute gene is important in maintaining the normal neuronal function in the mouse. The authors report the isolation and sequencing of [open quotes]myoxin[close quotes] (MYH12), the human homologue of the mouse dilute gene, and its assignment to human chromosome 15. 35 refs., 6 figs.

• OSTI ID: 6483436
• Journal Information: Genomics; (United States), Vol. 19:3; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENES
DNA SEQUENCING
DNA-CLONING
HUMAN CHROMOSOME 15
GENETIC MAPPING
MYOSIN
BIOTECHNOLOGY
CHROMOSOMES
CLONING
DNA HYBRIDIZATION
GENETIC ENGINEERING
GLOBULINS
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
NUCLEIC ACID HYBRIDIZATION
ORGANIC COMPOUNDS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics